Blood biomarkers of early diagnosis for neonatal bacterial infections: back from Senegal cohort
| Autor: | Abdourahmane Samba, Julie Durif, Vincent Sapin, Moustapha Djite, Fatou Cissé, Fatou Diallo Agne, Karen Coste, Halimatou Diop Ndiaye, Idrissa Yahya Soumah, Bruno Pereira, Pape Madieye Gueye, Ndèye Ramatoulaye Diagne Gueye, Fatou Diedhiou, Arame Ndiaye, Souleymane Thiam, Najah Fatou Gueye Coly, Idrissa Bass |
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| Rok vydání: | 2021 |
| Předmět: |
Calcitonin
medicine.medical_specialty Calcitonin Gene-Related Peptide Context (language use) Orosomucoid Procalcitonin Internal medicine Humans Medicine Protein Precursors Child Immunoturbidimetry biology business.industry Cost impact C-reactive protein Infant Newborn Bacterial Infections General Medicine Senegal C-Reactive Protein Early Diagnosis Blood biomarkers Cohort biology.protein business Biomarkers |
| Zdroj: | Annales de Biologie Clinique. 79:241-252 |
| ISSN: | 0003-3898 |
| DOI: | 10.1684/abc.2021.1650 |
| Popis: | In Senegal, reducing neonatal mortality remains a challenge. The management of neonatal infections remains problematic and presents a strong clinical focus. Indeed, like all developing countries, the difficulty of acquiring state-of-the-art infrastructure and the financial cost impact on the routine use of biomarkers. It is in this context that we conducted this study to identify the best biological strategy for making a reliable diagnosis. Ninety-nine newborns were recruited at the pediatric service of the Diamniadio Children's Hospital (Senegal). CRP was assayed by latex immuno-agglutination method, IL-6 and IL-8 using Luminex® technology, PCT by chemiluminescence, orosomucoid by immunoturbidimetry and SAA by ELISA technique. 20 newborns had probable infection and six established infection. Deaths and complications were significantly greater in these groups. With an optimal decision threshold of 16.3 mg/L, CRP performed better (compared to the other tested blood biomarkers) with AUC, sensitivity and specificity of 94%, 88% and 99%, respectively. With the performance obtained from CRP in the diagnosis of neonatal bacterial infections, the installation of panels with other biomarkers with advanced and expensive technology is not necessary. Thus, optimal care and within a reasonable timeframe can be done in our health facilities, with this accessible marker that is CRP. |
| Databáze: | OpenAIRE |
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