Supplementary Figures from Interactions between Ibrutinib and Anti-CD20 Antibodies: Competing Effects on the Outcome of Combination Therapy

Autor: Adrian Wiestner, Sarah E.M. Herman, Mohammed Z.H. Farooqui, Susan Soto, Janet Valdez, Constance Yuan, Katherine R. Calvo, Gerald E. Marti, Maryalice Stetler-Stevenson, Dalia Salem, Irina Maric, Sabrina Martyr, Yuh Shan Lee, Carsten U. Niemann, Martin Skarzynski
Rok vydání: 2023
Popis: Supplementary Figure 1. Uniform CD20 loss from the surface of primary CLL cells after in vivo exposure to ibrutinib. Supplementary Figure 2. Loss of CD20 on ibrutinib and basal CD20 expression levels do not correlate with high risk prognostic factors. Supplementary Figure 3. Selective NF-κB inhibitor diminishes CD20 cell surface expression. Supplementary Figure 4. Complement regulatory proteins membrane cofactor protein and protectin are not consistently inhibited by ibrutinib.
Databáze: OpenAIRE