Increased expressions of cellular ATP-binding cassette transporters may be a promising diagnostic marker for colorectal cancer
| Autor: | Huda A. Al Doghaither, Jihan Ghulam, Ulfat M. Omar, Ayat B. Al-Ghafari, Renad M. Qutub |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Male Abcg2 Colorectal cancer diagnosis lcsh:Medicine Gene Expression ATP-binding cassette transporter 030204 cardiovascular system & hematology Polymerase Chain Reaction Body Mass Index 0302 clinical medicine ATP Binding Cassette Transporter Subfamily G Member 2 030212 general & internal medicine Aged 80 and over biology ABCB1 General Medicine Middle Aged Neoplasm Proteins Real-time polymerase chain reaction Female Original Article Multidrug Resistance-Associated Proteins Colorectal Neoplasms Adult medicine.medical_specialty ATP Binding Cassette Transporter Subfamily B ABCG2 education ABCC1 Saudi Arabia colorectal cancer 03 medical and health sciences Internal medicine medicine Biomarkers Tumor Humans Aged business.industry lcsh:R Case-control study Diagnostic marker Transporter medicine.disease Case-Control Studies biology.protein ATP-Binding Cassette Transporters business Body mass index |
| Zdroj: | Saudi Medical Journal Saudi Medical Journal, Vol 41, Iss 8, Pp 834-840 (2020) |
| ISSN: | 0379-5284 |
| Popis: | Objectives : To measure the blood expression levels of related drug-resistant ATP-binding cassette (ABC) transporters in colorectal cancer (CRC) patients and to assess these examined transporters for whether they present signi cant expression in connection with the tumor appearance of CRC. Methods: In this case-control study, the messenger ribonucleic acids were isolated from the blood of 62 CRC patients who were recruited from King Abdulaziz University Hospital Oncology Clinic and 46 controls from King Fahad General Hospital Blood Bank (Jeddah, Saudi Arabia) from September 2016 to March 2017. The Biomedical Ethics Unit at King Abdulaziz University, Jeddah, Saudi Arabia approved this study. The expressions of ABC transporters were measured using quantitative polymerase chain reaction. GraphPad Prism 5 and REST 2009 Software were used to correlate the expressions with clinicopathological independent stages and body mass index. A p-value of less than 0.05 was considered significant. Results : Th e results showed that the 3 ABC transporters, particularly ABCC1 ( p less than 0.0001), were highly expressed in the blood of CRC patients compared with controls. However, none of the 3 transporters was related to the progression of CRC, age, gender, or body mass index. Conclusion : Th e expressions of ABC transporters were found to be significantly higher in CRC patients, and they may act as diagnostic markers and should potentially be tested for their contribution to drug sensitivity in CRC patients. Saudi Med J 2020; Vol. 41 (8): 834-840 doi: 10.15537/smj.2020.8.25187 How to cite this article: Renad M. Qutub, Ayat B. Al-Ghafari, Huda A. Al Doghaither, PhD, Ulfat M. Omar, PhD, Jihan M. Ghulam. Increased expressions of cellular ATP-binding cassette transporters may be a promising diagnostic marker for colorectal cancer. Saudi Med J 2020; Vol. 41 (8): 834-840. doi: 10.15537/smj.2020.8.25187. In this case all articles about the health in the mean of global warming influence may be related to the article by the link below: https://writemyfirstessay.com/global-warming-essay/ |
| Databáze: | OpenAIRE |
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