Motor abnormalities and cognitive impairment in first-episode psychosis patients, their unaffected siblings and healthy controls
| Autor: | Victor Peralta, J.M. López-Ilundain, Ana M. Sánchez-Torres, Teresa Cabada, Pablo Lecumberri, M. Sol Gómez, Ruth Lorente-Omeñaca, Manuel J. Cuesta, Lucía Moreno-Izco, María Ribeiro |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Audiology Akathisia 03 medical and health sciences 0302 clinical medicine medicine Humans Cognitive Dysfunction Genetic Predisposition to Disease Effects of sleep deprivation on cognitive performance Cognitive skill First-degree relatives Biological Psychiatry Movement Disorders Parkinsonism Siblings Cognition medicine.disease 030227 psychiatry Psychiatry and Mental health Cross-Sectional Studies Psychotic Disorders Schizophrenia Female medicine.symptom Psychology 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Schizophrenia research. 200 |
| ISSN: | 1573-2509 |
| Popis: | Motor abnormalities (MAs) may be already evidenced long before the beginning of illness and are highly prevalent in psychosis. However, the extent to which the whole range of MAs are related to cognitive impairment in psychosis remains understudied. This study aimed to examine comparatively the relationships between the whole range of motor abnormalities and cognitive impairments in the first-episode of psychosis (FEP), their unaffected siblings and healthy control subjects. Fifty FEP patients, 21 of their healthy siblings and 24 age- and sex matched healthy controls were included. Motor assessment included catatonic, extrapyramidal and neurological soft signs (NSS) by means of standardized instruments. An exhaustive neuropsychological battery was also performed to extract the 7 cognitive dimensions of MATRICS initiative. Higher scores on NSS but not on extrapyramidal and catatonic signs showed significant associations with worse cognitive performance in the three study groups. However, the pattern of associations regarding specific cognitive functions was different among the three groups. Moreover, extrapyramidal signs showed significant associations with cognitive impairment only in FEP patients but not in their unaffected siblings and healthy controls. Catatonic signs did not show any significant association with cognitive functioning in the three study groups. These findings add evidence to the associations between motor abnormalities, particularly NSS and extrapyramidal signs, and cognitive impairment in first-episode psychosis patients. In addition, our results suggest that the specific pattern of associations between MAs and cognitive functioning is different in FEP patients from those of the unaffected siblings and healthy subjects. |
| Databáze: | OpenAIRE |
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