Total synthesis and antibiotic activity of dehydrohomoplatencin
| Autor: | Floris P. J. T. Rutjes, Tanja Schülin-Casonato, Floris L. van Delft, Dennis C. J. Waalboer, Stefan H. A. M. Leenders |
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| Rok vydání: | 2010 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
medicine.medical_specialty medicine.drug_class Platensimycin Antibiotics Molecular Conformation Dehydrohomoplatencin Microbial Sensitivity Tests Aminophenols Crystallography X-Ray Catalysis World health chemistry.chemical_compound Human health medicine Enterococcus faecalis Polycyclic Compounds Intensive care medicine Nuclear Magnetic Resonance Biomolecular Pharmaceutical industry Molecular Structure Chemistry business.industry Organic Chemistry Stereoisomerism General Chemistry Anti-Bacterial Agents Streptococcus pneumoniae business |
| Zdroj: | Chemistry (Weinheim an der Bergstrasse, Germany). 16(37) |
| ISSN: | 1521-3765 |
| Popis: | The emergence of resistant pathogens is a rapidly increasing concern to society and has been identified by the World Health Organization (WHO) as one of the three greatest threats to human health. Unfortunately, the pressing need for new classes of antibiotics is still poorly met by the pharmaceutical industry, as illustrated by the recent call by the Infectious Diseases Society of America (IDSA) for a global commitment to develop ten new antibiotics by 2020. In this respect, the recent discovery of two new antibiotics, platensimycin (1) and platencin (2), represented a potential breakthrough in antibiotic research. |
| Databáze: | OpenAIRE |
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