Efficacy and tolerability of brodimoprim at two different dosage schedules in the treatment of acute uncomplicated bacterial cystitis: comparative study vs. pefloxacin
Autor: | E. V. Cosmi, G. C. Di Renzo, F. Abate, L. Mearini, P.A.Monici Preti, G. Balsotti, F. Scarpello, R. Indraccolo, G. B. La Sala, E. Cirese, Massimo Minozzi, L. Cantini, Gianfranco Carlomagno |
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Rok vydání: | 1996 |
Předmět: |
Adult
Male Strangury medicine.medical_specialty Urinalysis media_common.quotation_subject Urine acute bacterial cystitis brodimoprim pefloxacin Urination Drug Administration Schedule Trimethoprim Pefloxacin Acute bacterial cystitis chemistry.chemical_compound Anti-Infective Agents Internal medicine Cystitis medicine Humans Dysuria Aged media_common Brodimoprim medicine.diagnostic_test business.industry Obstetrics and Gynecology Bacterial Infections Middle Aged Surgery Treatment Outcome Reproductive Medicine Tolerability chemistry Acute Disease Female medicine.symptom business medicine.drug |
Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 64:207-211 |
ISSN: | 0301-2115 |
Popis: | In an open study, 172 male and female adult patients with acute uncomplicated bacterial cystitis were randomly allocated to three treatment groups. Two groups received brodimoprim 200 mg tablets as follows: a single dose of two 200 mg tablets on day 1, followed by one tablet per day on days 2 and 3 (58 patients); or a single daily dose of two tablets, for 2 days (63 patients). The third group received a single dose of pefloxacin, as two 400 mg tablets, for 1 day (51 patients). Complete urinalysis, sediment and urine culture examinations were carried out before treatment and 10 days after the last dose. Evaluation also comprised, at the time of enrolment and 48 h after the last dose, measurement of corporal temperature and assessment of symptoms (dysuria, pollakiuria, strangury, suprapubic pain, burning sensation during urination and urgency) on a 4-point scale. The eradication rate for the pathogen concerned was 98.3% and 96.7% in the groups receiving brodimoprim for 3 and 2 days, respectively, and 92.8% in the pefloxacin group (between-group comparison n.s.). There was significant regression of symptoms (P0.001) in the three groups (between-groups comparison n.s.). Mainly gastrointestinal adverse events occurred in 3 patients receiving brodimoprim for 2 days and in 4 patients from each of the other two groups. |
Databáze: | OpenAIRE |
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