Familial Risk of Biliary Tract Cancers: A Population-Based Study in Utah
| Autor: | Juan F. Gallegos-Orozco, Kenneth M. Boucher, Michael Charlton, Kathryn R. Byrne, N. Jewel Samadder, Cathryn Koptiuch, Heidi A. Hanson, Karen Curtin, Randall W. Burt, Ken R. Smith, Jathine Wong |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Physiology Population Adenocarcinoma Gastroenterology Cholangiocarcinoma Young Adult 03 medical and health sciences 0302 clinical medicine Bile Ducts Extrahepatic Utah Internal medicine medicine Familial predisposition Humans Family Genetic Predisposition to Disease Registries Gallbladder cancer education Aged Proportional Hazards Models Aged 80 and over education.field_of_study Proportional hazards model business.industry Gallbladder Middle Aged Hepatology medicine.disease Pedigree Cancer registry Bile Ducts Intrahepatic Biliary Tract Neoplasms medicine.anatomical_structure Bile Duct Neoplasms Biliary tract 030220 oncology & carcinogenesis Female Gallbladder Neoplasms 030211 gastroenterology & hepatology business |
| Zdroj: | Digestive Diseases and Sciences. 61:3627-3632 |
| ISSN: | 1573-2568 0163-2116 |
| Popis: | Biliary tract cancers (BTC) including, cholangiocarcinoma (CC) and gallbladder cancer (GBC), are rare and highly fatal malignancies. The etiology and inherited susceptibility of both malignancies are poorly understood. We quantified the risk of BTC in first-degree (FDR), second-degree (SDR), and first cousin (FC) relatives of individuals with BTC, stratified by tumor subsite. BTC diagnosed between 1980 and 2011 were identified from the Utah Cancer Registry and linked to pedigrees from the Utah Population Database. Age- and gender-matched BTC-free controls were selected to form the comparison group for determining BTC risk in relatives using Cox regression analysis. Of the 1302 index patients diagnosed with BTC, 550 (42.2 %) were located in the gallbladder and 752 (57.8 %) were cholangiocarcinomas. There was no elevated risk of BTC (all subsites combined) in FDRs (HR 0.94, 95 % CI 0.29–3.0), SDRs (HR 0.25, 95 % CI 0.06–1.03), and FCs (HR 0.96, 95 % CI 0.61–1.51) of BTC cases compared to cancer-free controls. Similarly, no increased familial risk of GBC or CC was found in relatives of BTC patients stratified by tumor subsite compared to relatives of controls. Relatives of BTC patients are not at an increased risk of GBC or CC in a statewide population. This suggests that biliary tract cancer risk is not associated with a familial predisposition and may be mitigated more strongly by environmental modifiers. |
| Databáze: | OpenAIRE |
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