Association Between Cerebral Microbleeds and Circulating Levels of Mid-Regional Pro-Adrenomedullin
| Autor: | Nagato, Kuriyama, Teruhide, Koyama, Etsuko, Ozaki, Satoshi, Saito, Masafumi, Ihara, Daisuke, Matsui, Isao, Watanabe, Masaki, Kondo, Yoshinori, Marunaka, Akihiro, Takada, Kentaro, Akazawa, Satomi, Tomida, Reo, Nagamitsu, Fumitaro, Miyatani, Masahiro, Miyake, Eri, Nakano, Daiki, Kobayashi, Yoshiyuki, Watanabe, Shigeto, Mizuno, Mizuho, Maekawa, Tamami, Yoshida, Yukiko, Nukaya, Toshiki, Mizuno, Kei, Yamada, Ritei, Uehara |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Alzheimer's Disease. 88:731-741 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-220195 |
| Popis: | Background: Mid-regional pro-adrenomedullin (MR-proADM) is a novel biomarker for cognitive decline based on its association with cerebral small vessel disease (SVD). Cerebral microbleeds (MBs) are characteristic of SVD; however, a direct association between MR-proADM and MBs has not been explored. Objective: We aimed to examine whether circulating levels of MR-proADM are associated with the identification of MBs by brain magnetic resonance imaging (MRI) and whether this association could be linked with cognitive impairment. Methods: In total, 214 participants (mean age: 75.9 years) without history of cerebral infarction or dementia were prospectively enrolled. All participants underwent brain MRI, higher cognitive function testing, blood biochemistry evaluation, lifestyle examination, and blood MR-proADM measurement using a time-resolved amplified cryptate emission technology assay. For between-group comparisons, the participants were divided into two groups according to whether their levels of MR-proADM were normal ( |
| Databáze: | OpenAIRE |
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