The relationship between liver histology and thyroid function tests in patients with non-alcoholic fatty liver disease (NAFLD)

Autor: D'Ambrosio, R., Campi, I., Maggioni, M., Perbellini, R., Giammona, E., Stucchi, R., Borghi, M., Degasperi, E., De Silvestri, A., Persani L., Fugazzola, L., Lampertico, P.
Rok vydání: 2020
Předmět:
Liver Cirrhosis
Male
Steatosis
endocrine system diseases
Peptide Hormones
Thyroid Gland
Thyroid Function Tests
Pathology and Laboratory Medicine
Severity of Illness Index
Biochemistry
Cytopathology
Endocrinology
Non-alcoholic Fatty Liver Disease
Medicine and Health Sciences
Thyroid
Liver Diseases
Histological Techniques
Middle Aged
Prognosis
C-Reactive Proteins
Liver
Medicine
Female
Anatomy
Research Article
Adult
endocrine system
Histology
Endocrine Disorders
Science
Endocrine System
Gastroenterology and Hepatology
digestive system
Hypothyroidism
Humans
Thyroid-Stimulating Hormone
Aged
Retrospective Studies
nutritional and metabolic diseases
Biology and Life Sciences
Proteins
Fibrosis
digestive system diseases
Hormones
Fatty Liver
Anatomical Pathology
Case-Control Studies
Follow-Up Studies
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0249614 (2021)
ISSN: 1932-6203
Popis: Background:Data on the role of hypothyroidism in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and liver fibrosis are conflicting, although selective Thyroid Hormone Receptor (THR)-β agonists have been identified as potential therapy in patients with non-alcoholic steatohepatitis (NASH). Therefore, we investigated the association between hypothyroidism and NAFLD histological features potentially associated with progressive liver disease. Methods:Between 2014 and 2016, consecutive patients with histologically proven NAFLD and frozen serum available for thyroid function tests assessment were included. NAFLD was staged according to the NAFLD Activity Score (NAS), and fibrosis according to Kleiner. NASH was defined as NAS ≥4, significant fibrosis as F2-F4 and significant steatosis as S2-S3. Thyroid function tests (TFT; TSH, FT3, FT4, rT3), TPO-Ab and Tg-Ab were also assessed. Results:Fifty-two patients were analyzed: median age 54 years, 58% females, LSM 7.8 kPa, 27% diabetics, 14% hypothyroid. At histology, NASH was present in 21 (40%), F2-F4 in 28 (54%) and S2-S3 in 30 (58%) patients. Rates of hypothyroidism were similar independently of the presence of NASH (p = 0.11), significant fibrosis (p = 0.21) or steatosis (p = 0.75). However, hypothyroid patients displayed a higher NAS (p = 0.02) and NASH (p = 0.06) prevalence. At multivariate analysis, TFT were not independently associated with histology. Conclusion:Hypothyroidism was highly prevalent in NAFLD patients, and was associated with increased NAFLD activity, but not with fibrosis and steatosis severity. Thus, thyroid dysfunction might play a direct and/or indirect in the pathogenesis of NAFLD and NASH.
Databáze: OpenAIRE
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