Pilot Study of Functional Magnetic Resonance Imaging Responses to Somatic Pain Stimuli in Youth With Functional and Inflammatory Gastrointestinal Disease
Autor: | Irina A. Strigo, Jeannie S. Huang, Laura Terrones, Alan N. Simmons, Walter H. Kaye |
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Rok vydání: | 2016 |
Předmět: |
Adult
Male medicine.medical_specialty Adolescent Pilot Projects interoception Medical and Health Sciences Inflammatory bowel disease Article Nociceptive Pain Irritable Bowel Syndrome Young Adult 03 medical and health sciences 0302 clinical medicine Alexithymia inflammatory bowel disease Internal medicine medicine Humans Young adult Irritable bowel syndrome Depression (differential diagnoses) Pain Measurement irritable bowel syndrome Brain Mapping Gastroenterology & Hepatology medicine.diagnostic_test business.industry Gastroenterology Inflammatory Bowel Diseases medicine.disease functional magnetic resonance imaging Magnetic Resonance Imaging Pediatrics Perinatology and Child Health Physical therapy Anxiety Female 030211 gastroenterology & hepatology Pain catastrophizing medicine.symptom Functional magnetic resonance imaging business 030217 neurology & neurosurgery |
Zdroj: | Journal of pediatric gastroenterology and nutrition, vol 63, iss 5 Huang, JS; Terrones, L; Simmons, AN; Kaye, W; & Strigo, I. (2016). Pilot Study of Functional Magnetic Resonance Imaging Responses to Somatic Pain Stimuli in Youth With Functional and Inflammatory Gastrointestinal Disease. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 63(5), 500-507. doi: 10.1097/MPG.0000000000001390. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/44h7k3rc |
ISSN: | 1536-4801 0277-2116 |
Popis: | Author(s): Huang, Jeannie S; Terrones, Laura; Simmons, Alan N; Kaye, Walter; Strigo, Irina | Abstract: BackgroundBrain-gut axis signaling modifies gastrointestinal symptomatology. Altered neural processing of intestinal pain signals involves interoceptive brain regions in adults with functional and inflammatory gastrointestinal disorders. Although these disorders frequently present in childhood, there are no published studies in youth. We determined whether neural processing of somatic pain stimuli differs in adolescents and young adults (AYA) with irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), as compared to healthy controls (HC).MethodsIBS and IBD AYA (16-20 years) underwent anticipated and thermal pain stimuli of low and high intensity on their forearm and simultaneous blood oxygen level-dependent functional magnetic resonance imaging. Data from adult HC were used for comparison. Subjects answered surveys evaluating alexithymia, anxiety, depression, and pain catastrophizing. Group data were compared using linear mixed effects and analysis of variance.ResultsStudy groups were similar by sex but not age. Significant group by pain condition interactions were observed in interoceptive brain regions during pain anticipation, and within perceptual brain regions during perceived pain. Higher activation within interoceptive brain regions during anticipated pain was observed in IBS compared with IBD and HC subjects. IBD patients demonstrated increased activation in perceptual brain regions during experienced pain as compared to IBS and HC.ConclusionsIBS and IBD AYA demonstrate altered neural processing of somatic pain compared with each other and with HC. Our results suggest that neuromodulatory interventions targeting interoceptive brain circuits in IBS and perceptual brain regions in IBD may be effective. |
Databáze: | OpenAIRE |
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