Pilot Study of Functional Magnetic Resonance Imaging Responses to Somatic Pain Stimuli in Youth With Functional and Inflammatory Gastrointestinal Disease

Autor: Irina A. Strigo, Jeannie S. Huang, Laura Terrones, Alan N. Simmons, Walter H. Kaye
Rok vydání: 2016
Předmět:
Adult
Male
medicine.medical_specialty
Adolescent
Pilot Projects
interoception
Medical and Health Sciences
Inflammatory bowel disease
Article
Nociceptive Pain
Irritable Bowel Syndrome
Young Adult
03 medical and health sciences
0302 clinical medicine
Alexithymia
inflammatory bowel disease
Internal medicine
medicine
Humans
Young adult
Irritable bowel syndrome
Depression (differential diagnoses)
Pain Measurement
irritable bowel syndrome
Brain Mapping
Gastroenterology & Hepatology
medicine.diagnostic_test
business.industry
Gastroenterology
Inflammatory Bowel Diseases
medicine.disease
functional magnetic resonance imaging
Magnetic Resonance Imaging
Pediatrics
Perinatology and Child Health
Physical therapy
Anxiety
Female
030211 gastroenterology & hepatology
Pain catastrophizing
medicine.symptom
Functional magnetic resonance imaging
business
030217 neurology & neurosurgery
Zdroj: Journal of pediatric gastroenterology and nutrition, vol 63, iss 5
Huang, JS; Terrones, L; Simmons, AN; Kaye, W; & Strigo, I. (2016). Pilot Study of Functional Magnetic Resonance Imaging Responses to Somatic Pain Stimuli in Youth With Functional and Inflammatory Gastrointestinal Disease. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 63(5), 500-507. doi: 10.1097/MPG.0000000000001390. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/44h7k3rc
ISSN: 1536-4801
0277-2116
Popis: Author(s): Huang, Jeannie S; Terrones, Laura; Simmons, Alan N; Kaye, Walter; Strigo, Irina | Abstract: BackgroundBrain-gut axis signaling modifies gastrointestinal symptomatology. Altered neural processing of intestinal pain signals involves interoceptive brain regions in adults with functional and inflammatory gastrointestinal disorders. Although these disorders frequently present in childhood, there are no published studies in youth. We determined whether neural processing of somatic pain stimuli differs in adolescents and young adults (AYA) with irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), as compared to healthy controls (HC).MethodsIBS and IBD AYA (16-20 years) underwent anticipated and thermal pain stimuli of low and high intensity on their forearm and simultaneous blood oxygen level-dependent functional magnetic resonance imaging. Data from adult HC were used for comparison. Subjects answered surveys evaluating alexithymia, anxiety, depression, and pain catastrophizing. Group data were compared using linear mixed effects and analysis of variance.ResultsStudy groups were similar by sex but not age. Significant group by pain condition interactions were observed in interoceptive brain regions during pain anticipation, and within perceptual brain regions during perceived pain. Higher activation within interoceptive brain regions during anticipated pain was observed in IBS compared with IBD and HC subjects. IBD patients demonstrated increased activation in perceptual brain regions during experienced pain as compared to IBS and HC.ConclusionsIBS and IBD AYA demonstrate altered neural processing of somatic pain compared with each other and with HC. Our results suggest that neuromodulatory interventions targeting interoceptive brain circuits in IBS and perceptual brain regions in IBD may be effective.
Databáze: OpenAIRE
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