The effects of lipoic acid on redox status in brain regions and systemic circulation in streptozotocin-induced sporadic Alzheimer’s disease model

Autor: Karolin Yanar, Seval Aydin, Ufuk Çakatay, Ahmet Dogukan Kansu, Mert Celikten, Ahmet Belce, Mehmet Evren Erdoğan, Tamer Cebe, Murat Mengi
Přispěvatelé: BELCE, Ahmet
Rok vydání: 2017
Předmět:
0301 basic medicine
medicine.medical_specialty
Antioxidant
medicine.medical_treatment
Hippocampus
medicine.disease_cause
Biochemistry
Antioxidants
Streptozocin
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Alzheimer Disease
Internal medicine
medicine
Animals
Cerebral Cortex
Glucose Transporter Type 2
Amyloid beta-Peptides
Glucose Transporter Type 3
Thioctic Acid
Transporter
Metabolism
Streptozotocin
Cortex (botany)
Disease Models
Animal
Oxidative Stress
Lipoic acid
030104 developmental biology
Endocrinology
chemistry
Erdogan M. E.
AYDIN S.
YANAR K.
Mengi M.
Kansu A. D.
Cebe T.
BELCE A.
Celikten M.
ÇAKATAY U.
-The effects of lipoic acid on redox status in brain regions and systemic circulation in streptozotocin-induced sporadic Alzheimer-s disease model-
METABOLIC BRAIN DISEASE
cilt.32
ss.1017-1031
2017
Neurology (clinical)
Oxidation-Reduction
030217 neurology & neurosurgery
Oxidative stress
medicine.drug
Zdroj: Metabolic Brain Disease. 32:1017-1031
ISSN: 1573-7365
0885-7490
DOI: 10.1007/s11011-017-9983-6
Popis: While the deterioration of insulin-glucose metabolism (IGM), impaired redox homeostasis (IRH), β-amyloid accumulation was reported in Sporadic Alzheimer's Disease (SAD) model, aforementioned factors related to lipoic acid administration and anthropometric indexes (AIs) are not yet studied with integrative approach. β-amyloid accumulation, redox homeostasis biomarkers and AIs are investigated in SAD model. Streptozotocin-induced inhibition of insulin-signaling cascade but not GLUT-2 and GLUT-3 transporters takes a role in β-amyloid accumulation. Inhibition types are related to IRH in cortex, hippocampus and systemic circulation. Lipoic acid (LA) shows both antioxidant and prooxidant effect according to the anatomical location. LA administration also leads to improved AIs during GLUT-2 inhibition and cortical redox status in GLUT-3 inhibited group. Optimal LA action could be possible if its redox behavior is balanced to antioxidant effect. Diagnostic usage of systemic IRH parameters as biomarkers and their possible correlations with deteriorated IGM should be investigated. Graphical abstract ᅟ.
Databáze: OpenAIRE
Externí odkaz: