Clinical outcome of early glottic carcinoma in Serbia
| Autor: | P. Stankovic, Aleksandar Trivic, Bojan Banko, Vera Artiko, Snezana Jesic, Borivoj B. Babic, Milorad Petrovic, Aleksandar Milovanović, Ana Jotic, Vojko Djukic, Jovica Milovanovic |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Laser surgery Glottis medicine.medical_specialty Voice Quality medicine.medical_treatment Laryngectomy Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Early Medical Intervention medicine Carcinoma Humans Prospective Studies 030223 otorhinolaryngology Prospective cohort study Laryngeal Neoplasms Survival rate Aged Radiotherapy business.industry General Medicine Middle Aged medicine.disease 3. Good health Surgery Radiation therapy Observational Studies as Topic Treatment Outcome medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Lasers Gas Cordectomy Female Laser Therapy business Serbia |
| Zdroj: | Auris Nasus Larynx. 40:394-399 |
| ISSN: | 0385-8146 |
| DOI: | 10.1016/j.anl.2012.11.013 |
| Popis: | Objective Proposed methods for treating early glottic carcinoma are cordectomy through laryngofissure, laser cordectomy, and radiotherapy. The aim of the study was to conduct comprehensive study to evaluate oncological and functional results of different treatment modalities for Tis and T1 glottic carcinoma, identify prognostic factors for the outcome of treatment and decide where we stand in applying worldwide standards of early glottic carcinoma treatment. Methods Prospective study was conducted on 221 patients treated with Tis and T1 glottic carcinoma from 1998 to 2003 (72 patients were treated endoscopically with CO 2 laser, 75 patients with cordectomy through laryngofissure and 74 with radiotherapy), with follow-up period from 38 to 107 months. Important demographic and clinical variables were analyzed. Voice quality after the treatment was assessed using multidimensional voice analysis. Results Comparing oncological results of three modalities of treatment, there were no significant differences. Functional results of treatment were better after laser cordectomy and primary radiotherapy than following the open cordectomy. Five-year survival rate was almost identical in all three groups of patients, and important prognostic factors for survival were age and histological grade of the tumor. Conclusion Considering that the choice of treatment in our country is also greatly influenced by other paramedical factors, such as distance from treatment facility, reliability of follow-up, significant time delay of radiotherapy because of small number of radiology centers and strong patients’ surgeon and treatment preference, we consider endoscopic laser surgery highly efficient and preferred choice of treatment for early glottic carcinoma. |
| Databáze: | OpenAIRE |
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