Use of Vincristine and Cyclosporine in Childhood Thrombotic Thrombocytopenic Purpura
| Autor: | Chun-Peng Chao, Claudio Sandoval, Barbara Cuccovia, Somasundaram Jayabose, Oya Levendoglu-Tugal, M Fevzi Ozkayanak |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Hemolytic anemia medicine.medical_specialty Vincristine Time Factors Adolescent medicine.medical_treatment Thrombotic thrombocytopenic purpura Gastroenterology Mixed connective tissue disease Refractory Internal medicine medicine Humans Child Chemotherapy Purpura Thrombotic Thrombocytopenic business.industry Plasmapheresis Hematology medicine.disease Ciclosporin Surgery Treatment Outcome Oncology Pediatrics Perinatology and Child Health Cyclosporine Female business medicine.drug |
| Zdroj: | Journal of Pediatric Hematology/Oncology. 25:421-425 |
| ISSN: | 1077-4114 |
| Popis: | Thrombotic thrombocytopenic purpura (TTP) is a rare but life-threatening hematologic disorder in children. Plasmapheresis, the standard therapy for TTP, is effective in achieving remission in most patients. However, some patients become either refractory to or dependent upon plasmapheresis. The authors report three such patients in whom the use of vincristine or vincristine plus cyclosporine resulted in permanent remission. A 12-year-old girl with TTP dependent on plasmapheresis for more than 5 months responded to vincristine with a decrease in the required frequency of plasmapheresis, but the addition of cyclosporine abrogated the need for further plasmapheresis. She subsequently developed serologic evidence of systemic lupus erythematosus. Two 15-year-old boys with TTP (one of them with underlying mixed connective tissue disease) became refractory to plasmapheresis after a brief initial response. The addition of vincristine in one patient and vincristine and cyclosporine in the second (with mixed connective tissue disease) led to complete remission. The authors' experience in this case study of three patients suggests that vincristine and cyclosporine are effective agents in the management of patients with TTP who do not achieve complete remission with plasmapheresis alone. |
| Databáze: | OpenAIRE |
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