In vitro antibacterial properties of BRL 36650, a novel 6 alpha-substituted penicillin
| Autor: | R. J. Ponsford, S. J. White, R. A. Edmondson, S. J. Knott, B Slocombe, M.J. Basker |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Cefotaxime
Ceftazidime Microbial Sensitivity Tests Penicillins Aztreonam beta-Lactamases Microbiology chemistry.chemical_compound Drug Stability Enterobacteriaceae polycyclic compounds medicine Humans Pharmacology (medical) Antibacterial agent Pharmacology Bacteria Gram-Negative Aerobic Bacteria biology Blood Proteins biology.organism_classification Anti-Bacterial Agents Penicillin Cefoperazone Infectious Diseases chemistry Pseudomonas aeruginosa Bacteroides fragilis Research Article Protein Binding medicine.drug Piperacillin |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 26:734-740 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.26.5.734 |
| Popis: | BRL 36650 is a new type of penicillin in which a formamido group has been introduced into the 6 alpha-position of the nucleus. The compound is highly active against aerobic gram-negative bacteria and is stable to a wide range of beta-lactamases produced by these organisms. Against members of the family Enterobacteriaceae, BRL 36650 was considerably more active than piperacillin, particularly against beta-lactamase-producing strains, and showed a similar level of activity to moxalactam, aztreonam, and the third-generation cephalosporins cefotaxime and ceftazidime. Against Pseudomonas aeruginosa and other Pseudomonas species, BRL 36650 was more active than piperacillin, cefoperazone, and aztreonam and compared favorably with ceftazidime. BRL 36650 was highly active against Haemophilus influenzae and Neisseria gonorrhoeae, including beta-lactamase-producing strains, and against Acinetobacter calcoaceticus. Clinical isolates of Enterobacter species and P. aeruginosa which showed markedly reduced susceptibility to cefotaxime, ceftazidime, and aztreonam were only slightly less susceptible to BRL 36650. Against Bacteroides fragilis and most gram-positive bacteria, BRL 36650 showed only a low level of activity. BRL 36650 was found to be only 35% bound to human serum protein, and the antibacterial activity was little affected by the presence of serum. In contrast, the composition of the test medium influenced the activity of BRL 36650 slightly, and an antagonistic effect could be demonstrated between the compound and a component of certain Mueller-Hinton media. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|