Optical-resolution photoacoustic microscopy of ischemic stroke
| Autor: | Enhao Gong, Konstantin Maslov, Brian T. Soetikno, Lihong V. Wang, Song Hu, Jin-Moo Lee, Ernie Gonzales, Ping Yan |
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| Přispěvatelé: | Oraevsky, Alexander, Wang, Lihong V. |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
business.industry Traumatic brain injury Hemoglobin oxygen saturation Infarction Hemodynamics medicine.disease complex mixtures respiratory tract diseases Photoacoustic microscopy Internal medicine Ischemic stroke medicine Cardiology Middle cerebral artery occlusion cardiovascular diseases business Stroke |
| Popis: | A major obstacle in understanding the mechanism of ischemic stroke is the lack of a tool to noninvasively or minimally invasively monitor cerebral hemodynamics longitudinally. Here, we applied optical-resolution photoacoustic microscopy (OR-PAM) to longitudinally study ischemic stroke induced brain injury in a mouse model with transient middle cerebral artery occlusion (MCAO). OR-PAM showed that, during MCAO, the average hemoglobin oxygen saturation (sO2) values of feeder arteries and draining veins within the stroke core region dropped ~10% and ~34%, respectively. After reperfusion, arterial sO2 recovered back to the baseline; however, the venous sO2 increased above the baseline value by ~7%. Thereafter, venous sO2 values were close to the arterial sO2 values, suggesting eventual brain tissue infarction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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