Risk factors affecting cardiac left-ventricular hypertrophy and systolic and diastolic function in the chronic phase of allogeneic hematopoietic cell transplantation
| Autor: | Asao Hirose, Takahiko Nakane, Yoshitaka Nakao, Hideo Koh, Masayuki Hino, Hirohisa Nakamae, Mitsutaka Nishimoto, Mika Nakamae, Kiyoyuki Hagihara, Masahiko Ohsawa, Yoshiki Terada |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cardiac function curve medicine.medical_specialty Time Factors Transplantation Conditioning Adolescent Left ventricular hypertrophy Models Biological Ventricular Function Left Muscle hypertrophy Postoperative Complications Risk Factors Internal medicine Linear regression medicine Humans Transplantation Homologous Aged Retrospective Studies Transplantation Ejection fraction business.industry Hematopoietic Stem Cell Transplantation Retrospective cohort study Hematology Middle Aged medicine.disease Surgery Regimen Echocardiography Hematologic Neoplasms Chronic Disease Linear Models Cardiology Female Hypertrophy Left Ventricular business |
| Zdroj: | Bone Marrow Transplantation. 48:581-586 |
| ISSN: | 1476-5365 0268-3369 |
| DOI: | 10.1038/bmt.2012.179 |
| Popis: | Chronic impairment of cardiac function can be an important health risk and impair the quality of life, and may even be life-threatening for long-term survivors of allogeneic hematopoietic cell transplantation (HCT). However, risk factors for and/or the underlying mechanism of cardiac dysfunction in the chronic phase of HCT are still not fully understood. We retrospectively investigated factors affecting cardiac function and left-ventricular hypertrophy (LVH) in the chronic phase of HCT. Sixty-three recipients who survived for >1 year after receiving HCT were evaluated using echocardiography. Based on simple linear regression models, high-dose TBI-based conditioning was significantly associated with a decrease in left-ventricular ejection fraction and the early peak flow velocity/atrial peak flow velocity ratio, following HCT (coefficient=-5.550, P=0.02 and coefficient=-0.268, P=0.02, respectively). These associations remained significant with the use of multiple linear regression models. Additionally, the serum ferritin (s-ferritin) level before HCT was found to be a significant risk factor for LVH on multivariable logistic analysis (P=0.03). In conclusion, our study demonstrated that a myeloablative regimen, especially one that involved high-dose TBI, impaired cardiac function, and that a high s-ferritin level might be associated with the development of LVH in the chronic phase of HCT. |
| Databáze: | OpenAIRE |
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