Curcumin improves alcoholic fatty liver by inhibiting fatty acid biosynthesis
| Autor: | Longxin Qiu, Tianxing Hu, Jingfan Ma, Longping Wen, Qionghong Zhong, Mengyuan Zhao, Tong Chen, Chang Guo |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Curcumin Glucuronate Linoleic acid Glyoxylate and dicarboxylate metabolism Pentose phosphate pathway Biology Toxicology Pentose Phosphate Pathway Mice 03 medical and health sciences chemistry.chemical_compound Glucuronic Acid Animals Metabolomics Pharmacology Ethanol Anti-Inflammatory Agents Non-Steroidal Fatty Acids Central Nervous System Depressants Galactose Oleic acid 030104 developmental biology Liver chemistry Biochemistry Alcoholic fatty liver Drug metabolism Fatty Liver Alcoholic |
| Zdroj: | Toxicology and Applied Pharmacology. 328:1-9 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/j.taap.2017.05.001 |
| Popis: | Alcoholic fatty liver is a threat to human health. It has been long known that abstinence from alcohol is the most effective therapy, other effective therapies are not available for the treatment in humans. Curcumin has a great potential for anti-oxidation and anti-inflammation, but the effect on metabolic reconstruction remains little known. Here we performed metabolomic analysis by gas chromatography/mass spectrometry and explored ethanol pathogenic insight as well as curcumin action pattern. We identified seventy-one metabolites in mouse liver. Carbohydrates and lipids were characteristic categories. Pathway analysis results revealed that ethanol-induced pathways including biosynthesis of unsaturated fatty acids, fatty acid biosynthesis and pentose and glucuronate interconversions were suppressed by curcumin. Additionally, ethanol enhanced galactose metabolism and pentose phosphate pathway. Glyoxylate and dicarboxylate metabolism and pyruvate metabolism were inhibited in mice fed ethanol diet plus curcumin. Stearic acid, oleic acid and linoleic acid were disease biomarkers and therapical biomarkers. These results reflect the landscape of hepatic metabolism regulation. Our findings illustrate ethanol pathological pathway and metabolic mechanism of curcumin therapy. |
| Databáze: | OpenAIRE |
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