Donor Selection in HLA-Mismatched Hematopoietic Stem Cell Microtransplantation for Acute Myeloid Leukemia
| Autor: | Yi Wang, Xiangjun Liu, Xinrong Zhan, Wan-Jun Sun, Jian-Hui Qiao, Qi-Yun Sun, Kai-Xun Hu, Bo Cai, Zheng Dong, Mei Guo, Chang-Lin Yu, Hui-Sheng Ai |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Adolescent medicine.medical_treatment KIR Ligand Graft vs Host Disease Hematopoietic stem cell transplantation Human leukocyte antigen Biology Disease-Free Survival Donor Selection 03 medical and health sciences Young Adult 0302 clinical medicine parasitic diseases Granulocyte Colony-Stimulating Factor medicine Humans Donor selection Remission Induction Hematopoietic stem cell Myeloid leukemia Cell Biology Hematology Middle Aged Hematopoietic Stem Cells Microtransplantation Leukemia Myeloid Acute 030104 developmental biology medicine.anatomical_structure Cancer research Female 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Stem cells and development. 29(10) |
| ISSN: | 1557-8534 |
| Popis: | To remedy the lack of human leukocyte antigen (HLA)-matched donors and address the problems bedeviling traditional allogeneic hematopoietic stem cell transplantation which induces the resultant graft-versus-host disease, we designed a scheme called HLA-mismatched hematopoietic stem cell microtransplantation (MST) for patients with acute myeloid leukemia (AML), where encouraging results were achieved. In providing answers to such questions as how to select the donors of MST and which factors were involved in the outcome of MST. One hundred thirty-one AML patients from four centers with lower or standard risk of prognosis after complete remission were given three courses of MST: high dose of cytarabine plus infusion of granulocyte colony-stimulating factor mobilized peripheral blood stem cells from HLA-mismatched donors. Leukemia-free survival (LFS) and overall survival were compared, with respect to gender difference, number of HLA-matched loci, killer cell immunoglobulin-like receptor (KIR), and ligand mismatch between donors and recipients. Median LFS of recipients with different KIR ligands from those of donors was found to be significantly higher than that of recipients having identical ligands with donors ( |
| Databáze: | OpenAIRE |
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