Guidelines for proton pump inhibitor prescriptions in paediatric intensive care unit
| Autor: | S Dauger, S Prot-Labarthe, Olivier Bourdon, M. Bellaïche, P. Joret-Descout |
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| Rok vydání: | 2017 |
| Předmět: |
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medicine.medical_specialty Pediatrics Adolescent medicine.drug_class Pharmaceutical Science Proton-pump inhibitor Pharmacy Intensive Care Units Pediatric Toxicology Off-label use law.invention 03 medical and health sciences 0302 clinical medicine law medicine Humans Pharmacology (medical) Prospective Studies 030212 general & internal medicine Medical prescription Child Pharmacology Dose-Response Relationship Drug business.industry Stress ulcer Infant Newborn Infant Proton Pump Inhibitors Off-Label Use medicine.disease Intensive care unit Child Preschool Practice Guidelines as Topic Emergency medicine Gastroesophageal Reflux Female 030211 gastroenterology & hepatology Observational study Upper gastrointestinal bleeding business |
| Zdroj: | International Journal of Clinical Pharmacy. 39:181-186 |
| ISSN: | 2210-7711 2210-7703 |
| DOI: | 10.1007/s11096-016-0420-4 |
| Popis: | Background Stress ulcer prophylaxis (SUP) is recommended in some situations to prevent upper gastrointestinal bleeding and is a component of standard care for patients admitted to the intensive care unit (ICU). Proton pump inhibitors (PPIs), already among the most widely prescribed drug classes, are being increasingly used. Objective To describe PPI prescribing patterns and their changes after the dissemination of guidelines. Setting Paediatric ICU (PICU), Robert-Debre Teaching Hospital, Paris, France, which admits about 800 patients annually, from full-term neonates to 18-year-olds. Method Prospective observational study with two 6-week observation periods (July–August and September–October, 2013), before and after dissemination in the PICU of PPI prescribing guidelines. Main outcome measure Changes in PPI prescribing patterns (prevalence, dosage, and indication) after the guidelines. Results The number of patients admitted to the PICU was 77 (mean age 4.6 years [range 1 day–18 years]) before and 70 (mean age 3.8 years [range 1 day–17 years]) after the guidelines. During both periods, SUP was the most common reason for PPI prescribing. The proportion of patients prescribed PPIs dropped significantly, from 51% before the guidelines to 30% after the guidelines (p |
| Databáze: | OpenAIRE |
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