Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine
| Autor: | Yolanda E. Bogaert, R. Williams, Robert E. Rosenthal, P R Getson, Gary Fiskum |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Resuscitation
Pathology medicine.medical_specialty medicine.medical_treatment Ischemia Neurological disorder Pharmacology Severity of Illness Index Brain Ischemia Dogs In vivo medicine Animals Lactic Acid Advanced and Specialized Nursing Chemotherapy business.industry Brain Biological activity Long-term potentiation medicine.disease Heart Arrest medicine.anatomical_structure Cerebral cortex Lactates Female Neurology (clinical) Acetylcarnitine Energy Metabolism Cardiology and Cardiovascular Medicine business |
| Zdroj: | Stroke. 23:1312-1317 |
| ISSN: | 1524-4628 0039-2499 |
| Popis: | Mechanisms of ischemia/reperfusion brain injury include altered patterns of energy metabolism that may be amenable to pharmacological manipulation. The purpose of this study was to test the effectiveness of postischemic acetyl-L-carnitine administration on potentiation of metabolic recovery and prevention of neurological morbidity in a clinically relevant model of complete, global cerebral ischemia and reperfusion. Neurological deficit scoring as well as spectrophotometric and fluorescent assays of frontal cortex lactate and pyruvate levels were used in a canine model employing 10 minutes of cardiac arrest followed by restoration of spontaneous circulation for 2 or 24 hours. Dogs treated with acetyl-L-carnitine exhibited significantly lower neurological deficit scores (p = 0.0037) and more normal cerebral cortex lactate/pyruvate ratios than did vehicle-treated control animals. Postischemic administration of acetyl-L-carnitine potentiates normalization of brain energy metabolites and substantially improves neurological outcome in a clinically relevant model of global cerebral ischemia and reperfusion. |
| Databáze: | OpenAIRE |
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