Reduced morbidity by using LigaSure compared to conventional inguinofemoral lymphadenectomy in vulvar cancer patients: A randomized controlled trial

Autor: Henriette J. G. Arts, Corine M. Koopmans, Anne-Floor W. Pouwer, Johanna M.A. Pijnenborg, Joanna IntHout, Joanne A. de Hullu
Přispěvatelé: Targeted Gynaecologic Oncology (TARGON)
Rok vydání: 2020
Předmět:
medicine.medical_specialty
CARCINOMA
Vulvar Squamous Cell Carcinoma
SURGERY
Inguinal Canal
Groin
law.invention
03 medical and health sciences
0302 clinical medicine
All institutes and research themes of the Radboud University Medical Center
Postoperative Complications
Randomized controlled trial
law
Penile Carcinoma
medicine
Humans
Femur
Aged
Aged
80 and over
COMPLICATIONS
Vulvar cancer
Vulvar Neoplasms
business.industry
VESSEL SEALING SYSTEM
Surgical technique
Middle Aged
medicine.disease
Prognosis
Surgery
Women's cancers Radboud Institute for Health Sciences [Radboudumc 17]
Vulvar squamous cell carcinoma
medicine.anatomical_structure
Oncology
Inguinofemoral Lymphadenectomy
030220 oncology & carcinogenesis
AXILLARY DISSECTION
Carcinoma
Squamous Cell
Inguinofemoral lymphadenectomy
Feasibility Studies
Lymph Node Excision
030211 gastroenterology & hepatology
Female
Vulvar Carcinoma
Morbidity
Complication
business
Follow-Up Studies
Zdroj: Surgical Oncology-Oxford, 35, pp. 149-155
Surgical Oncology-Oxford, 35, 149-155
Surgical oncology-Oxford, 35, 149-155. ELSEVIER SCI LTD
ISSN: 1879-3320
0960-7404
Popis: Background: Inguinofemoral lymphadenectomy (IFL) is part of the surgical treatment of different malignancies of the genital tract and/or the lower limb including vulvar carcinoma, penile carcinoma and melanoma. IFL is associated with morbidity in up to 85% of the patients. The aims of this MAMBO-IC study (Morbidity And Measurement of the Body) are to study the feasibility of using LigaSure for IFL and to assess the differences in the incidence of short-term complications using LigaSure versus conventional IFL randomized within each individual patient.Methods: In this multicenter randomized controlled trial (RCT), women diagnosed with squamous cell carcinoma of the vulva with an indication for bilateral IFL were included. It was randomly assigned for which groin the LigaSure was used; the other groin was treated with conventional IFL (sharp/diathermia). We estimated the incidence of >= 1 complication(s) per groin using logistic regression and compared this between the two surgical methods, adjusting for possible confounders.Results: We included 40 groins of 20 patients. The estimated incidence of >= 1 complication(s) was 29% after LigaSure versus 70% after conventional IFL (risk difference 41% (95% CI 19-62), p Conclusions: This RCT shows that LigaSure for IFL is feasible and associated with significantly less short-term surgical complications compared to conventional IFL. Further studies with a larger sample size are needed to validate our findings. ISRCTN15057626.
Databáze: OpenAIRE
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