Reduced morbidity by using LigaSure compared to conventional inguinofemoral lymphadenectomy in vulvar cancer patients: A randomized controlled trial
Autor: | Henriette J. G. Arts, Corine M. Koopmans, Anne-Floor W. Pouwer, Johanna M.A. Pijnenborg, Joanna IntHout, Joanne A. de Hullu |
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Přispěvatelé: | Targeted Gynaecologic Oncology (TARGON) |
Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
CARCINOMA Vulvar Squamous Cell Carcinoma SURGERY Inguinal Canal Groin law.invention 03 medical and health sciences 0302 clinical medicine All institutes and research themes of the Radboud University Medical Center Postoperative Complications Randomized controlled trial law Penile Carcinoma medicine Humans Femur Aged Aged 80 and over COMPLICATIONS Vulvar cancer Vulvar Neoplasms business.industry VESSEL SEALING SYSTEM Surgical technique Middle Aged medicine.disease Prognosis Surgery Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] Vulvar squamous cell carcinoma medicine.anatomical_structure Oncology Inguinofemoral Lymphadenectomy 030220 oncology & carcinogenesis AXILLARY DISSECTION Carcinoma Squamous Cell Inguinofemoral lymphadenectomy Feasibility Studies Lymph Node Excision 030211 gastroenterology & hepatology Female Vulvar Carcinoma Morbidity Complication business Follow-Up Studies |
Zdroj: | Surgical Oncology-Oxford, 35, pp. 149-155 Surgical Oncology-Oxford, 35, 149-155 Surgical oncology-Oxford, 35, 149-155. ELSEVIER SCI LTD |
ISSN: | 1879-3320 0960-7404 |
Popis: | Background: Inguinofemoral lymphadenectomy (IFL) is part of the surgical treatment of different malignancies of the genital tract and/or the lower limb including vulvar carcinoma, penile carcinoma and melanoma. IFL is associated with morbidity in up to 85% of the patients. The aims of this MAMBO-IC study (Morbidity And Measurement of the Body) are to study the feasibility of using LigaSure for IFL and to assess the differences in the incidence of short-term complications using LigaSure versus conventional IFL randomized within each individual patient.Methods: In this multicenter randomized controlled trial (RCT), women diagnosed with squamous cell carcinoma of the vulva with an indication for bilateral IFL were included. It was randomly assigned for which groin the LigaSure was used; the other groin was treated with conventional IFL (sharp/diathermia). We estimated the incidence of >= 1 complication(s) per groin using logistic regression and compared this between the two surgical methods, adjusting for possible confounders.Results: We included 40 groins of 20 patients. The estimated incidence of >= 1 complication(s) was 29% after LigaSure versus 70% after conventional IFL (risk difference 41% (95% CI 19-62), p Conclusions: This RCT shows that LigaSure for IFL is feasible and associated with significantly less short-term surgical complications compared to conventional IFL. Further studies with a larger sample size are needed to validate our findings. ISRCTN15057626. |
Databáze: | OpenAIRE |
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