Urinary sodium/creatinine ratio is a predictor for fractional sodium excretion and related to age in patients with cystic fibrosis
| Autor: | Sabine Van daele, Evelien Snauwaert, Yannick Vande Weygaerde, Stephanie Van Biervliet, Dimitri Declercq, Heidi Schaballie, Eva Van Braeckel, Lieselot Peremans, Michiel Glorieus |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Vital capacity Sodium status sodium depletion Cystic Fibrosis Urinary system Sodium Salt Urology chemistry.chemical_element INFANTS CHILDREN Urine Sodium Chloride Urinalysis Cystic fibrosis Pediatrics FEV1/FVC ratio chemistry.chemical_compound Fractional sodium excretion medicine Medicine and Health Sciences Humans Creatinine business.industry Infant ADULTS Perinatology and Child Health medicine.disease chemistry Pediatrics Perinatology and Child Health GROWTH DEPLETION business Blood sampling |
| Zdroj: | JOURNAL OF CYSTIC FIBROSIS |
| ISSN: | 1569-1993 1873-5010 |
| Popis: | Electrolyte disturbances are common in patients with cystic fibrosis (CF). Current guidelines on monitoring sodium status are based on research in a small group of infants and require blood sampling. The aim of this study was to evaluate urinary salt parameters as a surrogate for sodium-status in different age-groups. Blood and urine samples for electrolytes were collected from 222 patients followed at the Ghent University Hospital CF-center. Fractional sodium excretion (FENa) and several urinary parameters were calculated. Clinical characteristics did not differ according to sodium status, defined as FENa0.5%. ROC analysis demonstrated that sodium/creatinine ratio (UNa/Creat) predicted the sodium status most accurately with high sensitivity and specificity (97 and 91% respectively). The UNa/Creat cut-off predicting a FENa0.5% differed significantly according to age. The UNa/Creat is an excellent marker for the sodium status defined as a FENa0.5%. However, different cut-offs according to age category should be applied. |
| Databáze: | OpenAIRE |
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