CSF monoamine levels in normal-weight bulimia: evidence for abnormal noradrenergic activity
| Autor: | J C Ballenger, S Lesser, R B Lydiard, G Hsu, G W Stuart, Mark D. Fossey, Walter H. Kaye, V Stevens, Laraia Mt, Patrick M. O'Neil |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
medicine.medical_specialty Metabolite media_common.quotation_subject Norepinephrine chemistry.chemical_compound Cerebrospinal fluid Dopamine Internal medicine Monoaminergic medicine Humans Biogenic Monoamines Bulimia media_common Neurotransmitter Agents Homovanillic Acid Appetite Hydroxyindoleacetic Acid Psychiatry and Mental health Endocrinology Monoamine neurotransmitter chemistry Female Serotonin Psychology medicine.drug |
| Zdroj: | American Journal of Psychiatry. 147:225-229 |
| ISSN: | 1535-7228 0002-953X |
| DOI: | 10.1176/ajp.147.2.225 |
| Popis: | Normal-weight bulimic patients have disturbed appetite, mood, and neuroendocrine function and often respond to antidepressants. Since these findings suggest abnormalities in brain monoaminergic pathways, the authors measured CSF monoamine concentrations in 27 normal-weight bulimic patients and 14 volunteers. Bulimic patients had a significantly lower mean CSF norepinephrine concentration. Levels of CSF 5-HIAA, the major serotonin metabolite, and CSF HVA, the major dopamine metabolite, were normal, although more frequent binge-eating in bulimic subjects was associated with a significantly lower CSF HVA level. Whether trait- or state-related, monoaminergic disturbances are part of this disorder's neurobiological syndrome. The lower CSF norepinephrine concentration suggests bulimia is not simply a variant of affective disorders. |
| Databáze: | OpenAIRE |
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