Neuropathological investigation of hypocretin expression in brains of dementia with Lewy bodies
Autor: | Eizo Iseki, Koji Kasanuki, Hiroshige Fujishiro, Daizo Kondo, Omi Katsuse, Heii Arai, Kenji Kosaka, Michiko Minegishi, Kiyoshi Sato, Hiroaki Hino |
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Rok vydání: | 2013 |
Předmět: |
Lewy Body Disease
Male Pathology medicine.medical_specialty Lateral hypothalamus Neuropeptide tau Proteins Neuropathology Biology Alzheimer Disease mental disorders medicine Humans Aged Aged 80 and over Neurons Orexins Amyloid beta-Peptides Lewy body Dementia with Lewy bodies General Neuroscience Neuropeptides Intracellular Signaling Peptides and Proteins Brain Neurofibrillary tangle Middle Aged medicine.disease Axons nervous system Case-Control Studies alpha-Synuclein Locus coeruleus Female Narcolepsy |
Zdroj: | Neuroscience letters. 569 |
ISSN: | 1872-7972 |
Popis: | Hypocretin (Hcrt) is a neuropeptide synthesized in the lateral hypothalamus (LHT) that plays a key role in maintaining arousal state. In Parkinson's disease (PD), a narcolepsy-like syndrome is commonly seen, and a previous study showed substantial Hcrt neuronal loss in accordance with PD severity. In the present study, we quantitatively examined Hcrt immunoreactivity and α-synuclein and tau pathologies in the LHT and locus coeruleus (LC) in dementia with Lewy bodies (DLB) (n=15), Alzheimer's disease (AD) (n=14), and controls (n=7). In the LHT, substantial Hcrt-positive neurons were detected in controls. In contrast, in DLB and AD, the numbers of both total neurons and Hcrt-positive neurons were significantly reduced. The reduction of the latter was significantly severer in DLB than in AD. In the LC of controls, many Hcrt-positive axonal terminals were found. In contrast, the amount of Hcrt immunoreactivity was significantly reduced both in DLB and AD. In DLB, some Lewy body (LB)-bearing neurons were detected in the LHT, but the Hcrt-positive neurons did not have any LBs. Meanwhile, some tau-positive neurofibrillary tangle (NFT)-bearing neurons were detected in the LHT, and Hcrt-positive neurons occasionally contained NFTs. We observed a significant negative correlation between the number of Hcrt-positive neurons in the LHT and the neurofibrillary stage (r=-0.67, p=0.0067), whereas no significant correlation was found between the number of Hcrt-positive neurons and the Lewy stage (r=-0.47, p=0.077). This is the first report clarifying the substantial loss of Hcrt neurons in the LHT and of Hcrt axonal terminals in the LC in DLB and the correlation between the severity of Hcrt neuronal loss and progression of neurofibrillary pathology. |
Databáze: | OpenAIRE |
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