Acute kidney failure following severe viper envenomation: clinical, biological and ultrasonographic aspects
| Autor: | Jean-Philippe Chippaux, Charles Frédéric Tchégnonsi N'Vènonfon, Patrick Stéphane Kouomboua Mfin, Abdou-Rahman Aguemon, Kofi-Mensa Savi de Tové, Blaise Adelin Tchaou, M. Chobli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment RC955-962 Poison control Toxicology Hemorrhagic disorder law.invention Antivenom Hematoma law Arctic medicine. Tropical medicine RA1190-1270 Internal medicine Hemorrhagic syndrome medicine Benin Snakebite Envenomation Subcapsular hematoma KDIGO business.industry urogenital system Research Acute kidney injury medicine.disease Intensive care unit Infectious Diseases QL1-991 Toxicology. Poisons Animal Science and Zoology Parasitology Hemodialysis Complication business Zoology |
| Zdroj: | Journal of Venomous Animals and Toxins including Tropical Diseases v.26 2020 The Journal of venomous animals and toxins including tropical diseases Universidade Estadual Paulista (UNESP) instacron:UNESP Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 26, Article number: e20200059, Published: 07 DEC 2020 The Journal of Venomous Animals and Toxins Including Tropical Diseases Journal of Venomous Animals and Toxins including Tropical Diseases |
| Popis: | Background: Acute kidney injury (AKI) is a frequent complication of snakebite envenomation, which is still little known in sub-Saharan Africa. This study aims to describe the clinical, biological and ultrasonographic aspects of AKI following severe snakebite envenomation managed in the intensive care unit. Method: A prospective observational survey was performed in Benin over a period of 18 months. All patients suffering severe snakebite envenomation (SBE) were included. The diagnosis of AKI was made using the KDIGO criteria. Kidney ultrasound exam was performed in all patients to assess internal bleeding and morphological and structural abnormalities of the kidneys. Results: Fifty-one cases of severe SBE were included. All patients presented inflammatory syndrome and showed abnormal WBCT whereas bleeding was found in 46 of them (90%). The median time to hospital presentation was three days. The majority of patients were male (M/F sex ratio = 1.55) and the median age was 26. Sixteen patients (31%) showed AKI according to the KDIGO criteria. Severe AKI (KDIGO stage 2 and 3) was observed in three patients, including one stage 2 and two stage 3. Kidney ultrasound revealed three cases of kidney capsular hematoma (6%), two cases of kidney hypertrophy (3%), three cases of kidney injury (4%), two stage 1 KDIGO and one stage 2 KDIGO. Only one patient benefited from hemodialysis. All patients showing AKI recovered without sequels. The median duration of hospital stays was four days. Seven patients died (14%) including four among the 16 AKI patients. Antivenom has been administered to 41 patients (80%). The comparison between patients without and with AKI did not show any significant difference except gender (p = 10-2). Conclusion: AKI is a common complication of severe snakebite envenomation. Resulting from inflammatory and hemorrhagic disorders, AKI may prove to be a short-term life-threatening factor. |
| Databáze: | OpenAIRE |
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