| Autor: |
Aigli G. Vakrakou, Lykourgos Kolilekas, Niki Lama, Spiros Katsanos, Grigorios Stratakos, Ilias Tsougos, Effrosyni Manali, Eirini Grigoriou, Katherina Psarra, Constantinos Kilidireas, Spiros Papiris, Nikolaos L. Kelekis, Elias J. Gialafos |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
European journal of clinical investigationREFERENCES. 52(5) |
| ISSN: |
1365-2362 |
| Popis: |
To evaluate the distribution of circulating immune cell subsets in peripheral blood of patients with sarcoidosis and investigate if there is an association with an underlying cardiac involvement.Eighty-five newly diagnosed treatment-naïve patients with sarcoidosis (50 women) were included in the study. All patients underwent a thorough cardiac investigation, including cardiac magnetic resonance imaging (CMR). Of all patients, 19 (23.53%) had myocardial involvement, and the NK subpopulation in these patients in peripheral blood was significantly decreased compared to patients without (n = 63, p = 0.001 and p = 0.003 respectively). The absolute number of NKT cells (CD3+CD16/56We found that low NK cell count in peripheral blood of patients with sarcoidosis is associated with cardiac involvement, and the number of NK-T cells correlates with CMR findings indicative of myocardial inflammation. This finding might have a potential clinical application in detecting clinically silent cardiac involvement in sarcoidosis and may also suggest potential targets for therapeutic interventions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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