NOD-like receptor signaling in inflammation-associated cancers: From functions to targeted therapies
| Autor: | Ruyan Li, Yuan Sirui, Yibang Zhang, Mengchen Ji, Mingxiang Shen, Dongsheng Shang, Peng Liu, Zhigang Tu, Lu Ziwen, Han Xu, Lanlan Liu, Zhiquan Liang, Hanqing Liu, Dewan Ren |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
MAPK/ERK pathway
Carcinogenesis Inflammasomes medicine.medical_treatment Phytochemicals Pharmaceutical Science NLR Proteins Biology medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Cancer stem cell Neoplasms Drug Discovery medicine Humans Molecular Targeted Therapy Cellular Senescence 030304 developmental biology Pharmacology Inflammation 0303 health sciences Biological Products Neovascularization Pathologic Cancer NOD-like receptor Inflammasome medicine.disease Cytokine Complementary and alternative medicine 030220 oncology & carcinogenesis Cancer cell Cancer research Molecular Medicine Cytokines Lipid Peroxidation medicine.drug Signal Transduction |
| Zdroj: | Phytomedicine : international journal of phytotherapy and phytopharmacology. 64 |
| ISSN: | 1618-095X |
| Popis: | Background Recently, many studies have reported that some botanicals and natural products were able to regulate NOD-like receptor signaling. NOD-like receptors (NLRs) have been established as crucial regulators in inflammation-associated tumorigenesis, angiogenesis, cancer cell stemness and chemoresistance. NLRs specifically sense pathogen-associated molecular patterns and respond by activating other signaling regulators, including Rip2 kinase, NF-κB, MAPK and ASC/caspase-1, leading to the secretion of various cytokines. Purpose The aim of this article is to review the molecular mechanisms of NOD-like receptor signaling in inflammation-associated cancers and the NLRs-targeted botanicals and synthetic small molecules in cancer intervention. Results Aberrant activation of NLRs occurs in various cancers, orchestrating the tissue microenvironment and potentiating neoplastic risk. Blocking NLR inflammasome activation by botanicals or synthetic small molecules may be a valuable way to prevent cancer progression. Moreover, due to the roles of NLRs in regulating cytokine production, NLR signaling may be correlated with senescence-associated secretory phenotype. Conclusion In this review, we discuss how NLR signaling is involved in inflammation-associated cancers, and highlight the NLR-targeted botanicals and synthetic small molecules in cancer intervention. |
| Databáze: | OpenAIRE |
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