Photodynamic Therapy for the Treatment of Squamous Cell Carcinoma Using Benzoporphyrin Derivative
| Autor: | Warren S. Grundfest, Richard Yamamoto, Ronald L. Moy, Thanassis Papaioannou, Jeffrey Marcus, Lynn Dimino‐Emme, Vani R. Pergadia, Wendy J. Snyder, Gary Lask, Edward Glassberg, Sandor G. Vari |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Radiation-Sensitizing Agents Pathology medicine.medical_specialty Porphyrins Skin Neoplasms medicine.medical_treatment Cell Mice Nude Photodynamic therapy Dermatology behavioral disciplines and activities Cicatrix Mice Nude mouse In vivo mental disorders Tumor Cells Cultured medicine Animals Humans Neoplasm Invasiveness Basal cell Photosensitizer Benzoporphyrin derivative Anaplasia Cell Nucleus Dye laser biology business.industry Remission Induction biology.organism_classification medicine.anatomical_structure Photochemotherapy Oncology Carcinoma Squamous Cell Laser Therapy business |
| Zdroj: | The Journal of Dermatologic Surgery and Oncology. 20:375-382 |
| ISSN: | 0148-0812 |
| Popis: | background . Photodynamic therapy (PDT) involves laser light excitation of a tumor-localizing photosensitizer to destroy neoplasms. Benzoporphyrin derivative (BPD) is a new photosensitizer with several favorable characteristics. objective . Studies were designed to: 1) assess the efficacy of BPD-mediated PDT in treating in vivo squamous cell carcinomas (SCC); 2) obtain dosimetry data for BPD and laser parameters; and 3) establish clinical and histologic correlates of BPD-induced tumor regression. methods . Human SCC was implanted into nude mice. One group received BPD followed by laser light of 150 J/cm2 from an argon-pumped dye laser at 690 nm. Three control groups included laser energy alone, BPD alone, and no treatment. results . At day 21 posttreatment only PDT-treated tumors showed a statistically significant decrease in tumor volume and complete cure rate. Clinical resolution (scar) correlated perfectly with histologic resolution (scar). conclusions . Human SCC in a nude mouse model responds to BPD-mediated PDT. |
| Databáze: | OpenAIRE |
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