Modelling breast cancer in a TB fluoroscopy cohort: implications for the Dutch mammography screening
| Autor: | Fieke Dekkers, Harmen Bijwaard, Teun van Dillen |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Oncology
medicine.medical_specialty Neoplasms Radiation-Induced Tuberculosis Breast Neoplasms Comorbidity Risk Assessment Cohort Studies Breast cancer Risk Factors Internal medicine Prevalence medicine Humans Radiology Nuclear Medicine and imaging Netherlands Proportional Hazards Models Radiation Radiological and Ultrasound Technology business.industry Proportional hazards model Incidence (epidemiology) Public Health Environmental and Occupational Health General Medicine Middle Aged medicine.disease Fluoroscopy Cohort Female Radiology business Risk assessment Cohort study |
| Zdroj: | Radiation Protection Dosimetry. 143:370-374 |
| ISSN: | 1742-3406 0144-8420 |
| Popis: | Breast cancer incidence in a tuberculosis fluoroscopy cohort has been modelled with a two-stage carcinogenesis model. The relatively simple model, in which hormonal influences only affect the number of sensitive target cells, fits the data very well. Under the assumption that individual hormonal differences average out, and with a relative biological effectiveness for mammographic X rays of 1, the model yields ∼10 fatal breast cancer cases induced by the entire Dutch screening programme over a period of 25 y. This is much lower than derived from standard ICRP risk estimates and should be compared with the number of lives saved, which is estimated at ∼350 y(-1). As the extent of screening is currently being reconsidered in The Netherlands and elsewhere, this is an important result. |
| Databáze: | OpenAIRE |
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