Systemic network for dietary inorganic phosphate adaptation among three organs
| Autor: | Hiroko Segawa, Yasuko Ishikawa, Toru Fujii, Sawako Tatsumi, Yuji Shiozaki, Ai Hanazaki, Kayo Ikuta, Ken-ichi Miyamoto, Ichiro Kaneko |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Saliva Physiology Ductal cells Clinical Biochemistry Kidney Sodium-Phosphate Cotransporter Proteins Type IIb Salivary Glands Phosphates Excretion Mice 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine medicine Pi Animals Secretion Intestinal Mucosa Salivary gland Chemistry Adaptation Physiological Mice Inbred C57BL Renal Elimination 030104 developmental biology Endocrinology medicine.anatomical_structure Intestinal Absorption Phosphorus Dietary 030217 neurology & neurosurgery Homeostasis |
| Zdroj: | Pflügers Archiv - European Journal of Physiology. 471:123-136 |
| ISSN: | 1432-2013 0031-6768 |
| Popis: | Inorganic phosphate (Pi) secretion from the salivary glands and dietary Pi are key Pi sources. The regulatory mechanisms of Pi homeostasis in the salivary glands are unknown. We investigated how salivary Pi concentrations are regulated by dietary Pi in mouse models. Dietary manipulation significantly changed the levels of Npt2b protein in the salivary gland ductal cells. In addition, rapid feeding on a high-Pi diet increased the saliva Pi concentrations and led to rapid endocytosis of Npt2b in the apical membranes of the duct cells. Global Npt2b± mice exhibited increased salivary Pi concentrations and intestine-specific deletion of Npt2b after high Pi loading increased the salivary Pi concentrations. These findings indicate that Npt2b levels in the salivary glands affect the salivary Pi concentration and are regulated by dietary Pi. Intestinal Npt2b levels might also affect salivary Pi concentrations as well as renal Pi excretion. These findings suggest Pi is endogenously recycled by salivary Pi secretion, intestinal Pi absorption, and renal Pi excretion. |
| Databáze: | OpenAIRE |
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