Unexpected complication in a rat stroke model: exacerbation of secondary pathology in the thalamus by subacute intraarterial administration of human bone marrow-derived mesenchymal stem cells
| Autor: | Johanna Nystedt, Matti Korhonen, Bhimashankar Mitkari, Erja Kerkelä, Jukka Jolkkonen |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology medicine.medical_specialty Stromal cell Thalamus Infarction Mesenchymal Stem Cell Transplantation Brief Communication Cell therapy Medicine Animals Humans Rats Wistar Stroke Calcium metabolism Amyloid beta-Peptides business.industry Mesenchymal stem cell Infarction Middle Cerebral Artery medicine.disease Rats Disease Models Animal Neurology nervous system Calcium Neurology (clinical) Stem cell Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 35(3) |
| ISSN: | 1559-7016 |
| Popis: | This study examined whether human bone marrow mesenchymal stromal/stem cells (BMMSCs) could alleviate the secondary pathology in the thalamus after middle cerebral artery occlusion (MCAO) in rats. Atypical accumulation of both amyloid-β (Aβ) and calcium in the thalamus was significantly higher in rats receiving the BMMSCs infusion 48 hours after MCAO as compared with the vehicle MCAO group. The elevated Aβ/calcium accumulation correlated with the level of impaired sensorimotor function. Although secondary pathology in the thalamus seems to be rodent specific, it needs to be taken into account because it may impair long-term behavioral recovery and negate therapeutic treatment effects. |
| Databáze: | OpenAIRE |
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