Effect of Δ9-tetrahydrocannabinol on short-term memory in the rat
| Autor: | M.I. González, M.L. Leret, Francisco Molina-Holgado |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Serotonin medicine.medical_specialty medicine.medical_treatment Administration Oral Short-term memory Hippocampus Experimental and Cognitive Psychology Serotonergic Amygdala Behavioral Neuroscience Internal medicine medicine Animals Memory disorder Dronabinol Rats Wistar Maze Learning Tetrahydrocannabinol Brain Chemistry Behavior Animal medicine.disease Rats Memory Short-Term Endocrinology medicine.anatomical_structure Cerebral cortex Cannabinoid Psychology Neuroscience medicine.drug |
| Zdroj: | Physiology & Behavior. 57:177-179 |
| ISSN: | 0031-9384 |
| Popis: | We have reported that marihuana and its principal psycoactive compound, Δ 9 -tetrahydrocannabinol ( Δ 9 -THC) produce alterations in several cerebral areas after acute treatment. Based on the involvement of 5-hydroxytryptamine (5-HT) on memory and learning and the reported effects of Δ 9 -THC on short-term memory, we designed an experiment to evaluate the memory performance and its possible relationship with serotonergic alterations after Δ 9 -THC administration. Male Wistar rats received an acute oral dose of THC (5 mg/kg). Short-Term memory was tested on a radial 8-arm maze with a 5 s delay, after 35 days of trainning. The animals were food deprived and adjusted for growth. 5-HT and its metabolite, 5-HIAA, levels were measured in cerebral cortex, dorsal hippocampus, ventral hippocampus, rostral neoestriatum and amygdala basal nucleus, by HPLC-ED. The experiment indicates an impairment of short-term memory in the radial maze test after Δ 9 -THC administration. The control group performed the test without errors, while the treated group made a significant number of errors (Z = 0.019, Mann-Whitney test). This behavioral effect did not seem to be related to serotonergic alterations, as the 5-HT turnover rate was not different between treated and control animals. |
| Databáze: | OpenAIRE |
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