Combining Powder Formulations of Drugs with Food and Beverages to Improve Palatability
| Autor: | Noriyuki Namiki, Shimako Tanaka, Mai Sotoyama, Yasuharu Kashiwagura, Shinya Uchida |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Taste Visual analog scale score Drug Compounding Pharmaceutical Science Azithromycin Beverages Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Palatability Pharmacology Cross-Over Studies business.industry Carbocysteine General Medicine Anti-Bacterial Agents Pediatric patient 030104 developmental biology Food 030220 oncology & carcinogenesis Ice cream Anti-Infective Agents Local Female Powders business |
| Zdroj: | Biological and Pharmaceutical Bulletin. 43:1954-1959 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.b20-00491 |
| Popis: | The taste of medicines can significantly affect patient adherence. Pediatric patients often cannot take powder medicines because of their unpleasant taste. Therefore, patients' parents and health care professionals, including pharmacists, often combine medicines with food or beverages to make them easier for pediatric patients to consume because this can reduce their unpleasant taste. The purpose of this study was to evaluate the palatability of powder formulations of azithromycin and carbocysteine and explore their combination with food or beverages to improve palatability for pediatric patients. We quantitatively evaluated the palatability of powder formulations by performing the gustatory sensation test using the visual analog scale score. The gustatory sensation tests were performed on 16 healthy adult volunteers (age 23.0 ± 2.6 years) and indicated that some food and beverages improved the palatability of the powder formulations of azithromycin and carbocysteine. The results of this study indicate that ice cream improves the palatability of azithromycin, while yogurt improves the palatability of carbocysteine. Moreover, the subjects recommended these same combinations for pediatric patients. This study suggests that some foods and beverages improve the palatability of powder formulations, thereby decreasing the possibility that pediatric patients will refuse medications because of their unpleasant taste. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|