Convergent evolution of hemoglobin switching in jawed and jawless vertebrates
| Autor: | Margaret F. Docker, Friederike Stuhlmann, Thorsten Burmester, Kim Rohlfing |
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| Přispěvatelé: | University of Manitoba |
| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
Evolution Molecular 03 medical and health sciences chemistry.chemical_compound Hemoglobins Fetal hemoglobin Gene family Animals Ammocoete Globin Petromyzon Hemoglobin switching Phylogeny Ecology Evolution Behavior and Systematics biology Myoglobin Lamprey Cytoglobin Gnathostomata biology.organism_classification Agnatha Oxygen 030104 developmental biology chemistry Evolutionary biology Vertebrates Ontogeny Hemoglobin Research Article |
| Zdroj: | BMC Evolutionary Biology |
| ISSN: | 1471-2148 |
| DOI: | 10.1186/s12862-016-0597-0 |
| Popis: | Background During development, humans and other jawed vertebrates (Gnathostomata) express distinct hemoglobin genes, resulting in different hemoglobin tetramers. Embryonic and fetal hemoglobin have higher oxygen affinities than the adult hemoglobin, sustaining the oxygen demand of the developing organism. Little is known about the expression of hemoglobins during development of jawless vertebrates (Agnatha). Results We identified three hemoglobin switches in the life cycle of the sea lamprey. Three hemoglobin genes are specifically expressed in the embryo, four genes in the filter feeding larva (ammocoete), and nine genes correspond to the adult hemoglobin chains. During the development from the parasitic to the reproductive adult, the composition of hemoglobin changes again, with a massive increase of chain aHb1. A single hemoglobin chain is expressed constitutively in all stages. We further showed the differential expression of other globin genes: Myoglobin 1 is most highly expressed in the reproductive adult, myoglobin 2 expression peaks in the larva. Globin X1 is restricted to the embryo; globin X2 was only found in the reproductive adult. Cytoglobin is expressed at low levels throughout the life cycle. Conclusion Because the hemoglobins of jawed and jawless vertebrates evolved independently from a common globin ancestor, hemoglobin switching must also have evolved convergently in these taxa. Notably, the ontogeny of sea lamprey hemoglobins essentially recapitulates their phylogeny, with the embryonic hemoglobins emerging first, followed by the evolution of larval and adult hemoglobins. Electronic supplementary material The online version of this article (doi:10.1186/s12862-016-0597-0) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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