Brain Hypoxia Is Associated With Neuroglial Injury in Humans Post–Cardiac Arrest
| Autor: | Sophie Stukas, Jennifer Cooper, David K. Menon, Donald E. G. Griesdale, Mypinder S. Sekhon, Cheryl L. Wellington, Veronica Hirsch-Reinshagen, Sonny Thiara, Nicholas A Fergusson, Philip N. Ainslie, Denise Foster, Edward M. Conway, Peter Gooderham, Ryan L. Hoiland |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Physiology Inflammation tau Proteins 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Neurofilament Proteins Healthy volunteers Glial Fibrillary Acidic Protein Medicine Humans Post cardiac arrest Original Research business.industry partial pressure Interleukin-6 Brain Hypoxia brain injury 3. Good health Heart Arrest healthy volunteers inflammation Phosphopyruvate Hydratase Hypoxia-Ischemia Brain ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Biomarker (medicine) biomarker medicine.symptom Cardiology and Cardiovascular Medicine business Neuroglia Ubiquitin Thiolesterase 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Circulation Research |
| ISSN: | 1524-4571 0009-7330 |
| Popis: | Supplemental Digital Content is available in the text. Rationale: Secondary brain hypoxia portends significant mortality in ischemic brain diseases; yet, our understanding of hypoxic ischemic brain injury (HIBI) pathophysiology in humans remains rudimentary. Objective: To quantify the impact of secondary brain hypoxia on injury to the neurovascular unit in patients with HIBI. Methods and Results: We conducted a prospective interventional study of invasive neuromonitoring in 18 post–cardiac arrest patients with HIBI. The partial pressures of brain tissue O2 (PbtO2) and intracranial pressure were directly measured via intraparenchymal microcatheters. To isolate the cerebrovascular bed, we conducted paired sampling of arterial and jugular venous bulb blood and calculated the transcerebral release of biomarkers of neurovascular injury and inflammation in the patients with HIBI and 14 healthy volunteers for control comparisons. Ten patients with HIBI exhibited secondary brain hypoxia (PbtO2 |
| Databáze: | OpenAIRE |
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