Weekly 5-fluorouracil and folinic acid plus escalating doses of cisplatin with glutathione protection in patients with advanced head and neck cancer
| Autor: | Giuseppe Zerillo, Federico Ingria, G Cannata, Salvatore Restivo, Antonio Testa, Nicola Gebbia, Gianfranco Cupido, Giovanni Spadafora, Roberto Valenza, Vittorio Gebbia, Carmelo Barbaccia, Calogero Cipolla |
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| Přispěvatelé: | Gebbia, V., Valenza, R., Testa, A., Zerillo, G., Restivo, S., Cupido, G., Ingria, F., Spadafora, G., Barbaccia, C., Cannata, G., Cipolla, C., Gebbia, N. |
| Rok vydání: | 1992 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Urology Leucovorin Head/neck cancer Drug Administration Schedule Nephrotoxicity Catalysi Folinic acid Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans In patient Pharmacology (medical) Aged Cisplatin Hematology Dose-Response Relationship Drug business.industry Head and neck cancer Chemistry (all) Middle Aged medicine.disease Glutathione Oncology Fluorouracil Head and Neck Neoplasms Anesthesia Pharmacology Toxicology and Pharmaceutics (all) Toxicity Female Kidney Diseases Gluthatione business medicine.drug |
| Zdroj: | Medical oncology and tumor pharmacotherapy. 9(4) |
| ISSN: | 0736-0118 |
| Popis: | Twenty-two patients with advanced head and neck carcinoma were treated with 5FU 400 mg-2 m-1 week and folinic acid 500 mg m-2 week-1 plus CDDP in escalating doses from 20 to 40 mg m-2 week-1 without forced diuresis. Reduced gluthatione at the dose of 1.5 g m-2 was employed to protect patients from CDDP-related nephrotoxicity. The aims of the study were: a) to evaluate the therapeutic efficacy of this schedule, and b) to evaluate reduced gluthatione as uroprotector. Out of 20 evaluable patients 14 (70 %) had a major objective response. A CR with a mean duration of 9.0+ months was achieved in 15 % of the patients, a PR of 5.8+ months in 55 % of the patients, while 3 patients had stable disease and 4 progressed. It was possible to escalate CDDP up to 35 mg m-2 week-1, but at the dose of CDDP 40 mg m-2 week-1 the occurrence of grade 2 renal toxicity provoked a severe reduction of dose-intensity. Overall, this treatment has been very well tolerated by most patients with few cases of grade 3 gastrointestinal or hematological toxicity. In conclusion, the schedule seems effective and may be safely given to patients with advanced head and neck cancer on outpatient basis. Reduced gluthatione seems to be able to reduce, at least partially, CDDP-related nephrotoxicity permitting the delivery of higher CDDP doses. © 1992, Humana Press Inc.. All rights reserved. |
| Databáze: | OpenAIRE |
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