A comparative study of polychlorinated dibenzofurans, polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin on aryl hydrocarbon hydroxylase inducing potency in rats
| Autor: | Masanori Kuratsune, Yoshito Masuda, Hiroaki Kuroki, Junya Nagayama |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
medicine.medical_specialty Polychlorinated Dibenzodioxins Polymers Health Toxicology and Mutagenesis Spleen Dioxins Toxicology Structure-Activity Relationship Internal medicine medicine Animals Structure–activity relationship Potency Enzyme inducer Benzofurans Kidney biology Chemistry Rats Inbred Strains General Medicine Polychlorinated Biphenyls Rats medicine.anatomical_structure Endocrinology Enzyme Induction Bioaccumulation Environmental chemistry Toxicity biology.protein Aryl Hydrocarbon Hydroxylases Polychlorinated dibenzofurans |
| Zdroj: | Archives of Toxicology. 53:177-184 |
| ISSN: | 1432-0738 0340-5761 |
| Popis: | The aryl hydrocarbon hydroxylase (AHH) inducing potency of toxic chlorinated aromatic hydrocarbons such as polychlorinated dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was studied in the young male Wistar rats. Alternatively, a technical PCDF mixture, 15 individual PCDF isomers or TCDD were administered i.p. in doses of 5 micrograms/kg; a PCB mixture was given in a dose of 50 mg/kg. The order of AHH inducing ability was TCDD greater than PCDFs much greater than PCBs in kidney, lung, and liver. In the prostate, thymus, and spleen, only TCDD enhanced the AHH activity. The AHH inducibility in the lung and liver, induced by 15 pure PCDF isomers with varying chlorine substitutions was also examined. Only 2,3,7,8-tetrachlorodibenzofuran (2,3,7,8-tetra-CDF) and 2,3,4,7,8-pentachlorodibenzofurans (2,3,4,7,8-penta-CDF) significantly induced the hepatic AHH activity (4- and 2-fold, respectively), while eight PCDF isomers, including these two, significantly enhanced the pulmonary AHH activity (6- to 30-fold). Taking into account both the potent AHH inducibility and the high bioaccumulation of these compounds, 2,3,7,8-tetra- and 2,3,4,7,8-penta-CDF should be given due attention with regard to environmental-related factors and the possibility of involvement in the etiology of "yusho" disease. |
| Databáze: | OpenAIRE |
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