γδ T Cells Number, CD200, and Flt3 Expression Is Associated with Higher Progression Free Survival in Patients with Chronic Myeloid Leukemia
| Autor: | Elba Reyes-Maldonado, Jorge Vela-Ojeda, Ruth A. Lezama, Laura Montiel-Cervantes, Santa Victoria Anguiano-Peñaloza, Rubiraida Molina-Aguilar |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Lymphocyte Cell T-Lymphocytes Regulatory 03 medical and health sciences 0302 clinical medicine Immune system Antigens CD Leukemia Myelogenous Chronic BCR-ABL Positive medicine Humans CD135 Longitudinal Studies Lymphocyte Count Progression-free survival Immunologic Surveillance Proportional Hazards Models business.industry Myeloid leukemia Cancer Receptors Antigen T-Cell gamma-delta Dendritic Cells General Medicine Middle Aged medicine.disease Progression-Free Survival Killer Cells Natural Immunosurveillance 030104 developmental biology medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 fms-Like Tyrosine Kinase 3 030220 oncology & carcinogenesis Immunology Female business |
| Zdroj: | Archives of Medical Research. 51:194-203 |
| ISSN: | 0188-4409 |
| Popis: | Background Tumor immunoedition involves alterations in cells of immune system, which may play an important role in the immunosurveillance of patients with cancer diseases. Aim of the study To determine the association between the number of immune cells and the expression of surface markers in leukemic cells of patients with de novo CML who achieved molecular response. Methods A longitudinal study was conducted in 31 patients with de novo CML. Peripheral blood samples were obtained at diagnosis for quantification of immune cells and tumor cells expressing CD200, CD135, GpP, and Bcl-2. Results were compared with a group of 60 healthy donors. Lymphocyte subsets were analyzed during a 48 month follow-up period and molecular response to treatment was assessed simultaneously by QT-PCR. The group of patients with deep molecular response was compared with de novo CML patients; the cut-off value of cell count was determined by ROC analysis. Kaplan-Meier and Cox proportional hazard model were used to determine the significant association between the number of cells and progression-free survival. Results Differences in number of CD4, CD4Tregs, NK, γδT, monocytes, and pDC's, tumor-cells expressing CD200+, CD135+, GpP+, and Bcl-2+ were observed between patients and healthy donors. The number of γδT lymphocytes, CD200+, and CD135+ cells were associated with longer progression-free survival (p = 0.0112, p = 0.0012 and p = 0.0201 respectively). Conclusion A γδT lymphocyte count |
| Databáze: | OpenAIRE |
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