Heat Loss, Sleepiness, and Impaired Performance after Diazepam Administration in Humans
| Autor: | Hiroaki Kusanagi, Tadashi Ohkubo, Atsushi Sekine, Yasuo Hishikawa, Kazuo Mishima, Tetsuo Shimizu, Masaru Echizenya, Kohtoku Satoh |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Pharmacology Psychomotor learning Analysis of Variance Benzodiazepine Diazepam Adolescent medicine.drug_class Visual analogue scale Administration Oral Crossover study Hypnotic Psychiatry and Mental health Anesthesia Sedative medicine Humans Sleep onset Sleep Psychology Psychomotor Performance Body Temperature Regulation medicine.drug |
| Zdroj: | Neuropsychopharmacology. 28:1198-1206 |
| ISSN: | 1740-634X 0893-133X |
| DOI: | 10.1038/sj.npp.1300160 |
| Popis: | In spite of the accumulation of knowledge regarding the neuropharmacological action of benzodiazepines (Bz), the physiological process by which their sedative/hypnotic effects are induced remains poorly understood. We conducted a single-blind, crossover trial to evaluate the role of the thermoregulatory process in sleepiness and impaired psychomotor performance induced by a standard Bz, diazepam (DZP). Each of the eight healthy young male volunteers (mean age, 19.75 years; range, 18-23 years) was given a single oral dose of either 5 or 10 mg of DZP or placebo 12 h after his average sleep onset time. Changes in plasma DZP concentration, proximal body temperature (p-BT), distal body temperature (d-BT), subjective sleepiness measured by the Visual Analog Scale and Stanford Sleepiness Scale, and psychomotor performance measured by Choice Reaction Time were monitored under a modified constant routine condition in which various factors affecting thermoregulation, alertness, and psychomotor performances were strictly controlled. Orally administered DZP induced a significant transient decrease in p-BT and psychomotor performance as well as an increase in d-BT and subjective sleepiness. Distal-p-BT gradient (DPG; difference between d-BT and p-BT), which is an indicator of blood flow in distal skin regions, showed a strong positive correlation with the plasma DZP concentration, indicating that DZP in clinical doses promotes heat loss in a dose-dependent manner. The DPG also correlated positively with the magnitude of subjective sleepiness and impaired psychomotor performance. These findings indicate that the sedative/hypnotic effects of Bz could be due, at least in part, to changes in thermoregulation, especially in the process of heat loss, in humans. |
| Databáze: | OpenAIRE |
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