Clinical value of carcinoembryonic antigen in mammary neoplasms of bitches
| Autor: | Bruna Fernanda Firmo, Camila Goloni, Rodrigo Storti Pereira, Roberto Ampuero, Isabela Cristina Canavari, Mirela Tinucci-Costa, I.L.S. Senhorello, Felipe Augusto Ruiz Sueiro, Letícia Abrahão Anai, Erika M. Terra |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Nestlé Purina PetCare, VETPAT Pathology and Molecular Biology Laboratory |
| Rok vydání: | 2019 |
| Předmět: |
endocrine system
medicine.medical_specialty canine mammary tumour 040301 veterinary sciences Mammary Neoplasms medicine.medical_treatment Mammary gland Breast Neoplasms Mammary Neoplasms Animal Gastroenterology Sensitivity and Specificity Metastasis 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Blood serum Carcinoembryonic antigen CEA Dogs Internal medicine Biomarkers Tumor Medicine metastasis Animals Dog Diseases Neoplasm Staging General Veterinary biology business.industry biomarkers 04 agricultural and veterinary sciences medicine.disease Prognosis Carcinoembryonic Antigen medicine.anatomical_structure 030220 oncology & carcinogenesis Clinical value biology.protein Biomarker (medicine) Female prognosis business Mastectomy |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1476-5829 |
| Popis: | Made available in DSpace on 2020-12-12T01:00:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-09-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) This study aimed at evaluating the behaviour and understanding the diagnostic value of the carcinoembryonic antigen (CEA) in bitches with mammary carcinoma as a tool for monitoring and prognosis of canine cancer patients. Serum samples from 77 bitches were divided into four groups, G1 (n = 21), control group (healthy/neoplasia free bitches); G2 (n = 31), bitches with non-metastatic mammary carcinoma less than 3 cm; G3 (n = 12), bitches with non-metastatic mammary carcinoma greater than 3 cm; and, G4 (n = 13) bitches with mammary carcinoma and lymph node metastasis. The marker was dosed once in G1, whereas in G2, G3 and G4, CEA levels were determined before (M0) and 15 days after (M1) mastectomy, using the ELISA kit for humans while reading used ELISYS ONE human. A group of 11 bitches was followed up 45 days after mastectomy (M2). The results for the concentration of markers in blood serum samples at the evaluated times and their relationship with neoplasia biological behaviour and observed clinicopathological changes were evaluated by the Tukey test at 5% significance. The ROC curve was established to find the cut-off value and calculate the test sensitivity and specificity, the multivariate matching analysis was performed to confirm the association between CEA values and clinicopathological variables. CEA values increased significantly in bitches with mammary carcinoma, metastatic tumours with a diameter larger than 3.0 cm and high grade, compared with healthy ones. In addition, mastectomy reduced the CEA concentration in the blood (P |
| Databáze: | OpenAIRE |
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