Endogenous Release of Secretin From the Hypothalamus

Autor:	Wing-Ho Yung, Jessica Y. S. Chu, Billy K. C. Chow
Rok vydání:	2006
Předmět:	Male medicine.medical_specialty Central nervous system Hypothalamus Rats Inbred WF Neuropeptide Endogeny Biology General Biochemistry Genetics and Molecular Biology Potassium Chloride Receptors G-Protein-Coupled Receptors Gastrointestinal Hormone Secretin chemistry.chemical_compound History and Philosophy of Science Internal medicine medicine Animals Voltage-dependent calcium channel General Neuroscience Calcium channel Rats medicine.anatomical_structure Endocrinology chemistry Tetrodotoxin
Zdroj:	Annals of the New York Academy of Sciences. 1070:196-200
ISSN:	0077-8923
DOI:	10.1196/annals.1317.012
Popis:	P revious studies demonstrated that secretin could be re- leased from the cerebellum, where it exerts a facilitatory action on the GABAergic inputs into the Purkinje neurons. In the present article, we provide evidence of the endogenous release of secretin in the hypotha- lamus and the mechanisms underlying this release. Incubation of the hypothalamic explants with KCl induces the release of secretin to 4.35 ± 0.45-fold of the basal level. This K + -induced release was tetrodotoxin and cadmium sensitive, suggesting the involvement of voltage-gated sodium and calcium channels. The use of specific blockers further revealed the involvement of L-, N-, and P-type high voltage-activated (HVA) calcium channels. Results present in the current article provide further and more solid evidence of the role of secretin as a neuropeptide in the mammalian central nervous system.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2050338de0deeee691810bca7c8de94 https://doi.org/10.1196/annals.1317.012 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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