Lung carcinomas decrease the number of monocytes/macrophages (CD14+ cells) that produce TNF-α
| Autor: | Juan José Mandoki, Manuel Meneses-Flores, Dolores Aguilar-Cazares, Federico Avila-Moreno, Jose Sullivan Lopez-Gonzalez, Heriberto Prado-Garcia |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Lung Neoplasms CD14 medicine.medical_treatment Immunology Lipopolysaccharide Receptors Cell Count Cell Communication Adenocarcinoma Immunophenotyping Humans Immunology and Allergy Medicine Lung cancer Aged Aged 80 and over Lung Tumor Necrosis Factor-alpha business.industry Macrophages Monocyte Respiratory disease Cancer U937 Cells Middle Aged respiratory system medicine.disease Coculture Techniques medicine.anatomical_structure Cytokine Carcinoma Squamous Cell Female Tumor necrosis factor alpha business |
| Zdroj: | Clinical Immunology. 122:323-329 |
| ISSN: | 1521-6616 |
| DOI: | 10.1016/j.clim.2006.11.003 |
| Popis: | The role that inflammation plays in cancer is puzzling. In peripheral blood, TNF-alpha-producing monocytes (CD14+ cells) were compared among patients with lung cancer, patients with tuberculosis and healthy donors; also, in pleural effusion TNF-alpha-producing CD14+ cells were compared between tuberculous patients and lung cancer patients. To analyze the level of the cellular alteration in TNF-alpha production, an experimental model was set up. TNF-alpha-producing CD14+ cells in peripheral blood from lung cancer patients were significantly lower than those from healthy donors. In pleural effusion, TNF-alpha-producing CD14+ cells were significantly lower in lung cancer patients than in tuberculous patients. Based on the results obtained from an experimental model, we suggest that this phenomenon was attributed to a reduced expression of TNF-alpha transcript. These findings provide evidence that lung carcinomas reduce TNF-alpha production by macrophages, possibly by inducing in these cells an M2 phenotype, which favor tumor progression. |
| Databáze: | OpenAIRE |
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