Effect of insulin sensitivity on SHBG levels in premenopausal versus postmenopausal obese women

Autor: Fulya Akin, Esma Alkis, Mehmet Bastemir
Rok vydání: 2007
Předmět:
Blood Glucose
obesity
blood pressure measurement
retrospective study
medicine.medical_treatment
insulin blood level
Overweight
thyrotropin
Sex hormone-binding globulin
insulin resistance
Sex Hormone-Binding Globulin
middle aged
polycyclic compounds
Insulin
Pharmacology (medical)
Euthyroid
glucose
Gonadal Steroid Hormones
comparative study
pathophysiology
reproductive and urinary physiology
medicine.diagnostic_test
biology
adult
article
euthyroidism
General Medicine
Insulin sensitivity
sex hormone binding globulin
Lipids
Postmenopause
Menopause
aged
female
Postprandial
Sex steroids
medicine.symptom
hormones
hormone substitutes
and hormone antagonists
uric acid blood level
medicine.medical_specialty
premenopause
hormone blood level
sex hormone
Insulin resistance
uric acid
lipid
blood
estradiol
Internal medicine
medicine
cross-sectional study
Humans
controlled study
human
SHBG
Retrospective Studies
business.industry
medicine.disease
major clinical study
clinical feature
glucose blood level
thyrotropin blood level
Cross-Sectional Studies
Endocrinology
estradiol blood level
biology.protein
Lipid profile
business
Zdroj: Advances in Therapy. 24:1210-1220
ISSN: 1865-8652
0741-238X
DOI: 10.1007/bf02877767
Popis: This study was performed to evaluate the impact of insulin sensitivity on sex hormone-binding globulin (SHBG) and sex steroids in premenopausal and postmenopausal euthyroid obese women. A total of 227 women were eligible for this study. All were euthyroid, obese, and overweight; ages ranged from 25 to 69 years. Women were divided into premenopausal (n=151) and postmenopausal (n=76) groups. SHBG, sex steroids, thyrotropin, fasting and postprandial glucose, lipid profile, uric acid, serum insulin, and blood pressure were measured. No significant difference was found in mean SHBG levels between premenopausal and postmenopausal women. The investigators observed that during transition from premenopause to postmenopause, SHBG levels increased in insulin-sensitive women in the postmenopausal group; however, SHBG levels decreased in insulin-resistant women. It was concluded that SHBG blood concentration factors are likely to change during transition from premenopause to postmenopause. The positive effect of estradiol on SHBG levels is probably stronger in premenopausal women than in postmenopausal women. It has been noted that after menopause, the impact of insulin resistance on SHBG level seems more important than the effect of estradiol. ©2007 Health Communications Inc.
Databáze: OpenAIRE
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