Dendritic cells from different tissues induce production of different T cell cytokine profiles
| Autor: | David G. Lemak, Michael P. Everson, Kenneth W. Beagley, William J. Koopman, Jerry R. McGhee, Deborrah S. McDuffie |
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| Rok vydání: | 1996 |
| Předmět: |
Follicular dendritic cells
medicine.medical_treatment T cell Immunology Peyer's patch Dendritic Cells Cell Biology Th1 Cells Biology Lymphocyte Activation T cell cytokine production Cell biology Peyer's Patches Th2 Cells Immune system medicine.anatomical_structure Cytokine Interleukin 15 medicine Animals Cytokines Humans Immunology and Allergy Antigen-presenting cell Spleen |
| Zdroj: | Journal of Leukocyte Biology. 59:494-498 |
| ISSN: | 1938-3673 0741-5400 |
| Popis: | The precise role of antigen-presenting cells (APC) in regulating the balance of T-helper type 1 (Th1) and T-helper type 2 (Th2) cytokine production is unclear. Dendritic cells (DC), the most potent APC for activation of naive T cells, were found to regulate Th1 and Th2 cytokine profiles in a fashion dependent upon their tissue of origin. Spleen (systemic) DC induce mainly Th1 cytokines and Peyer’s patch (mucosal) DC induce predominantly Th2 cytokines. These findings support the current concept that different tissues, each with its distinct microenvironment of cytokines, hormones, and cellular elements, are involved in the selection, promotion, and/or maintenance of different immune responses. With regard to DC, it is apparent that the tissue of DC origin determines the cytokine profiles produced by T cells and that DC from different tissues favor either cellular versus humoral immune responses by influencing T cell cytokine production. |
| Databáze: | OpenAIRE |
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