Can bone turnover markers help to define the suitability and duration of bisphosphonate drug holidays?
| Autor: | Terry J. Aspray, Louise Statham, Sharon Abdy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Bone density medicine.medical_treatment Osteoporosis 030209 endocrinology & metabolism Gastroenterology 03 medical and health sciences 0302 clinical medicine N-terminal telopeptide Internal medicine medicine collagen type 1 Original Research sub_healthsciences Pharmacology sub_pharmacyandpharmacology business.industry Alendronic acid lcsh:RM1-950 General Medicine Drug holiday alendronate Bisphosphonate medicine.disease osteoporosis Discontinuation risedronic acid lcsh:Therapeutics. Pharmacology Risedronic acid Molecular Medicine diphosphonates 030101 anatomy & morphology business bone resorption bone remodelling medicine.drug |
| Zdroj: | Drugs in Context Drugs in Context, Vol 9, Pp 1-5 (2020) |
| ISSN: | 1740-4398 1745-1981 |
| Popis: | Background: On stopping bisphosphonate treatment, bone resorption may increase before evidence of a decrease in bone density. Offset of bisphosphonate effect may therefore be monitored by measuring C-terminal telopeptide (CTX) following long-term bisphosphonate treatment to inform clinical decisions on drug holiday. Methods: Retrospective analysis of 158 patients (83% female, mean age 71 years) starting a drug holiday had plasma CTX measured at discontinuation (baseline), n=138 and 4 months and n=136, and 12 months (n=100). Premenopausal mean CTX levels and the least significant change (LSC) detectable were used to define target thresholds for bone turnover. Results: Following long-term bisphosphonate treatment (69% alendronic acid, 33% risedronate, mean duration 8 years SD 2.7), 32% patients had CTX above target (0.19 μg/L). In those with baseline CTX below threshold, 28% increased CTX to >0.19 μg/L and > LSC (0.06 μg/L) by 4 months (mean CTX increase 0.05 μg/L [95% confidence interval (CI): 0.04–0.06; p |
| Databáze: | OpenAIRE |
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