Predictive Analysis of Gallbladder Wall Thickness as a Marker for Bleeding Risk and Need for Transfusion in Dengue Patients
| Autor: | Zohaib Yousaf, Farah Yasmin, Rabail Yaseen, Muhammad Sohaib Asghar, Saira Anwar, Muhammad Junaid Tahir |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Adult Gallbladder wall thickening medicine.medical_specialty Gastroenterology Sensitivity and Specificity Dengue fever Increased capillary permeability Dengue Young Adult Internal medicine Linear regression medicine Humans Platelet Retrospective Studies Receiver operating characteristic business.industry Gallbladder General Medicine Middle Aged medicine.disease Infectious Diseases Wall thickness business Major bleeding Biomarkers |
| Zdroj: | Japanese journal of infectious diseases. 75(3) |
| ISSN: | 1884-2836 |
| Popis: | Increased gallbladder wall thickening (GBWT) is one manifestation of increased capillary permeability caused by severe dengue. This study was carried out to link the severity of GBWT with the bleeding risk and the need for transfusion. It was conducted retrospectively including all the patients with a diagnosis of dengue infection either via Dengue nonstructural protein-1 (NS-1) antigen or IgM antibody. Pearson's correlation, linear regression and receiver operating characteristic (ROC) curves were used for predictive analysis of GBWT with event of bleeding and need for transfusion of platelets during the hospital stay. A total of 177 participants met the inclusion criteria with a mean age of 33.17 ± 13.63 years. Mean GBWT was found to be 0.37 ± 0.15 cm, with 46.3% of patients had a thickness greater than 0.30 cm. A total of 16 patients were documented with bleeding events out of which 7.3% had minor bleeding and 1.7% had a major bleeding event. Linear regression analysis showed increased GBWT was found associated with decreased platelet count on admission (p=0.002) and lowest platelet counts (p=0.004). GBWT was found predictive of bleeding event and transfusion of platelets at higher sensitivity and specificity than platelet count on admission and lowest platelet counts. |
| Databáze: | OpenAIRE |
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