Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar
| Autor: | Psychalakis Nikolaos, Kalodimou Vassiliki, Messini Irini, Papalois Apostolos, Angelou Valerie, Eleftheria Karampela |
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| Rok vydání: | 2016 |
| Předmět: |
lcsh:Internal medicine
Pathology medicine.medical_specialty Article Subject Population Adipose tissue 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Hyaluronic acid medicine lcsh:RC31-1245 030223 otorhinolaryngology education Molecular Biology education.field_of_study Lamina propria biology business.industry Mesenchymal stem cell Cell Biology Anatomy medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Vocal folds biology.protein Stem cell business Elastin Research Article |
| Zdroj: | Stem Cells International Stem Cells International, Vol 2016 (2016) |
| ISSN: | 1687-9678 1687-966X |
| DOI: | 10.1155/2016/9010279 |
| Popis: | Background. The aim of the study was to assess the histological effects of autologous infusion of adipose-derived stem cells (ADSC) on a chronic vocal fold scar in a rabbit model as compared to an untreated scar as well as in injection of hyaluronic acid.Study Design. Animal experiment.Method. We used 74 New Zealand rabbits. Sixteen of them were used as control/normal group. We created a bilateral vocal fold wound in the remaining 58 rabbits. After 18 months we separated our population into three groups. The first group served as control/scarred group. The second one was injected with hyaluronic acid in the vocal folds, and the third received an autologous adipose-derived stem cell infusion in the scarred vocal folds (ADSC group). We measured the variation of thickness of the lamina propria of the vocal folds and analyzed histopathologic changes in each group after three months.Results. The thickness of the lamina propria was significantly reduced in the group that received the ADSC injection, as compared to the normal/scarred group. The collagen deposition, the hyaluronic acid, the elastin levels, and the organization of elastic fibers tend to return to normal after the injection of ADSC.Conclusions. Autologous injection of adipose-derived stem cells on a vocal fold chronic scar enhanced the healing of the vocal folds and the reduction of the scar tissue, even when compared to other treatments. |
| Databáze: | OpenAIRE |
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