If At First You Don't Succeed, Trikafta Again

Autor:	India, Loyd, Nicole, Papac, Jason, Hirshburg, Jarad, Levin, Jennifer, Dannelley, Janislynn, Dorris, Jason, Stratton, Nighat, Mehdi
Rok vydání:	2022
Předmět:	Clinical Vignette Pediatrics Perinatology and Child Health Pharmacology (medical)
Zdroj:	J Pediatr Pharmacol Ther
ISSN:	2331-348X 1551-6776
DOI:	10.5863/1551-6776-27.5.467
Popis:	Adverse reactions, including severe cutaneous reactions, to cystic fibrosis transmembrane conductance regulator (CFTR) modulators have been described in the literature. Herein we present a drug eruption in response to elexacaftor/tezcaftor/ivacaftor (brand name, Trikafta) in a 7-year-old male with cystic fibrosis, followed by desensitization and successful continuation. A review of the literature outlining similar cases is provided. Attempting to mitigate and manage drug reactions to CFTR modulators is essential because they represent vital and irreplaceable therapies for individuals with cystic fibrosis (CF).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fb29728ccfbf21291ef8570feb7f10 https://doi.org/10.5863/1551-6776-27.5.467 Zobrazit plný text záznamu