Detection of diffuse skeletal lesions by monitoring the kinetics of labeled phosphonate
| Autor: | M. Poropat, Tezak S, Simonović L, Damir Dodig, Popović S |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Bone disease Kinetics Bone Neoplasms Urine Scintigraphy Metastasis Medicine Humans Radiology Nuclear Medicine and imaging In patient Radionuclide Imaging Aged Monitoring Physiologic Aged 80 and over medicine.diagnostic_test Diphosphonates business.industry General Medicine Organotechnetium Compounds Middle Aged medicine.disease Bone scintigraphy Female business Clearance |
| Zdroj: | Nuklearmedizin. Nuclear medicine. 33(1) |
| ISSN: | 0029-5566 |
| Popis: | SummaryA method of detecting of diffuse skeletal involvement in patients with metastatic tumors or with metabolic diseases is presented. The study consisted of 31 patients without bone disease and of 26 selected patients with diffuse skeletal involvement. The kinetics of 99mTc-dicarboxypropane diphos-phonate (DPD) were calculated by monitoring the plasma and urine concentrations up to 5 hours after administration. Using these data, the renal clearance as well as the increase in urinary excretion of 99mTc-DPD were determined. The results indicate that measurement of the quantity of 99mTc-DPD excreted in the urine after 3 hours allows a reliable separation of the patients with diffuse skeletal lesions from normals. Other calculations such as renal clearance as well as the drop in plasma concentration were less sensitive. The test may be performed simultaneously with bone scintigraphy without additional radiation burden to the patient. |
| Databáze: | OpenAIRE |
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